Chemical induced intracellular hyperthermia
AssigneeSaint Jude Pharmaceuticals, Inc.
InventorsNicholas Bachynsky, Woodie Roy
Life of this patent
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Abstract
An invention relating to therapeutic pharmacological agents and methods to chemically induce intracellular hyperthermia and/or free radicals for the diagnosis and treatment of infections, malignancy and other medical conditions. The invention relates to a process and composition for the diagnosis or killing of cancer cells and inactivation of susceptible bacterial, parasitic, fungal, and viral pathogens by chemically generating heat, and/or free radicals and/or hyperthermia-inducible immunogenic determinants by using mitochondrial uncoupling agents, especially 2,4 dinitrophenol and, their conjugates, either alone or in combination with other drugs, hormones, cytokines and radiation.
Claims9
A method for inducing intracellular hyperthermia in a subject comprising the step of administering to a subject having an infection of Borrelia burgdorferi, Mycobacterium leprae, Treponema pallidum, HIV, hepatitis C, or herpes virus, an amount of 2,4-dinitrophenol sufficient to induce whole body intracellular hyperthermia in the subject, wherein the whole body intracellular hyperthermia is sufficient to treat the Borrelia burgdorferi, Mycobacterium leprae, Treponema pallidum, HIV, hepatitis C, or herpes virus infection in the subject.
A method for inducing intracellular hyperthermia in a subject comprising the step of administering to a subject having an infestation of Sporothrix schenkii, Histoplasma, paracoccidiodes, Aspergillus, Leishmania, malaria, acanthamoeba, or cestodes, an amount of 2,4-dinitrophenol sufficient to induce whole body intracellular hyperthermia in the subject, wherein the whole body intracellular hyperthermia is sufficient to treat the Sporothrix schenkii, Histoplasma, Paracoccidiodes, Aspergillus, Leishmania, malaria, acanthamoeba or cestodes infestation in the subject.
Dependencies are inferred from the claim text.