Porcine reproductive and respiratory syndrome isolates and methods of use
AssigneeBoehringer Ingelheim Vetmedica GmbH
InventorsMichael Roof, Eric Vaughn, Wesley Johnson
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Abstract
A method of predicting the virulence of a new or uncharacterized PRRS virus strain is provided wherein the strain is injected into swine and allowed to replicate for a period of from about 3-15 days. During this period, the rate of virus growth and/or the magnitude of viremia is determined, and this data is compared with a corresponding growth rate and/or viremia magnitude of a PRRS virus strain of known virulence, as a measure of the virulence of the new or uncharacterized strain.
Claims11
A method of predicting the virulence of a PRRS virus strain of unknown virulence, comprising the steps of administering a quantity of said PRRS virus strain into PRRS-free swine, allowing the virus to replicate in said swine for a period of from about 3-15 days, quantitatively measuring the rate of virus growth and/or the magnitude of viremia in said swine more than once during said period, and comparing said rate of growth or viremia magnitude with the rate of growth and/or viremia magnitude of more than one PRRS virus strain of known virulence as a predictor of virulence of a PRRS strain of unknown virulence.
A method of predicting the virulence of a PRRS virus strain of unknown virulence, comprising the steps of administering a quantity of said PRRS virus strain into PRRS-free swine, allowing the virus to replicate in said swine for a period of from about 3-15 days, quantitatively measuring the rate of virus growth and/or the magnitude of viremia using Log10 TCID50/ml in said swine more than once during said period, and comparing said rate of growth or viremia magnitude with the rate of growth and/or viremia magnitude of more than one PRRS virus strain of known virulence as a predictor of virulence of a PRRS strain of unknown virulence.
Dependencies are inferred from the claim text.