Categorization of microbial communities
AssigneeIdaho Research Foundation, Inc.
InventorsLarry J. Forney, James Foster, Celeste Brown, Paul Joyce, Zaid Abdo, Audra Johnson, Xia Zhou
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Abstract
The present disclosure provides methods for defining one or more microbial communities. In an example, the method can include providing a plurality of microbial profiles, wherein each microbial profile is established from a sample of microorganisms obtained from an individual subject. The method can also include identifying one or more consensus profiles from among the plurality of microbial profiles. These methods can be used to characterize normal and pathological microflora in vaginal samples.
Claims32
A method of defining one or more normal vaginal microbial communities, the method comprising:
- obtaining a plurality of single vaginal samples, wherein each single sample comprises vaginal microorganisms obtained from a female without vaginal pathology;
- using analytical laboratory techniques to obtain a plurality of microbial profiles, wherein each microbial profile is obtained from the single sample of vaginal microorganisms obtained from a female without vaginal pathology;
- identifying a plurality of consensus profiles from among the plurality of microbial profiles, thereby defining a plurality of normal vaginal microbial communities, wherein the plurality of consensus profiles comprise the seven supergroups shown in Table 2;
- and
- providing the plurality of consensus profiles to a user.
A method of defining one or more normal vaginal microbial communities, the method comprising:
- obtaining a plurality of single vaginal samples, wherein each single sample comprises vaginal microorganisms obtained from a female without vaginal pathology;
- using analytical laboratory techniques to obtain a plurality of microbial profiles, wherein each microbial profile is obtained from the single sample of vaginal microorganisms obtained from a female without vaginal pathology;
- identifying a plurality of consensus profiles from among the plurality of microbial profiles, thereby defining a plurality of normal vaginal microbial communities, wherein the plurality of consensus profiles comprises the five supergroups shown in Table 3;
- and
- providing the plurality of consensus profiles to a user.
Dependencies are inferred from the claim text.