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US 7,627,381 B2Granted

Systems and methods for combined RF-induced hyperthermia and radioimmunotherapy

AssigneeTherm Med, LLC

InventorsJohn Kanzius, William Harry Steinbrink, Robert J. McDonald, Michael J. Keating

Life of this patent

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Abstract Drawings Claims Description

Abstract

A combined radiotherapy and hyperthermia therapy is provided, including inducing hyperthermia in at least a portion of a target area—e.g., a tumor or a portion of a tumor or targeted cancerous cells—is provided. Biomolecules labeled with at least one radionuclide suitable for radiotherapy are provided and introduced into a patient; targeted RF absorption enhancers are provided and introduced into a patient; and a hyperthermia generating RF signal is directed via toward the target cells, thereby warming the radionuclide-labeled biomolecules and targeted RF absorption enhancers bound to target cells. The targeted RF absorption enhancers may, in a manner of speaking, add one or more RF absorption frequencies to cells in the target area, which will permit a hyperthermia generating RF signal at that frequency or frequencies to heat the targeted cells. Biomolecules labeled with at least one radionuclide suitable for radiotherapy may be used for both radiotherapy and as RF absorption enhancers for the hyperthermia generating RF signal.

Claims72

Dependent claims

Claim 1A method of inducing hyperthermia in at least target cells of a patient · 249 words38 dependent Claim 23A method of inducing hyperthermia in at least target cells of a patient · 282 words21 dependent Claim 43A method of inducing hyperthermia in at least target cells of a patient · 273 wordsNo dependents Claim 46A method of inducing hyperthermia in at least target cells of a patient · 306 wordsNo dependents Claim 49A method of inducing hyperthermia in at least target cells of a patient · 241 words6 dependent Claim 51A method of inducing hyperthermia in at least target cells of a patient · 286 wordsNo dependents Claim 52A method of inducing hyperthermia in at least target cells of a patient · 286 wordsNo dependents Claim 53A method of inducing hyperthermia in at least target cells of a patient · 290 wordsNo dependents Claim 54A method for inducing hyperthermia in target cells in a patient · 159 wordsNo dependents Claim 55A method for inducing hyperthermia in target cells in a patient · 180 wordsNo dependents Claim 56A method for inducing hyperthermia in target cells in a patient · 176 wordsNo dependents Claim 57A method for inducing hyperthermia in target cells in a patient · 197 wordsNo dependents Claim 58A method for inducing hyperthermia in target cells in a patient · 192 wordsNo dependents Claim 65A method of inducing hyperthermia in at least target cells of a patient · 278 wordsNo dependents Claim 68A method of inducing hyperthermia in at least target cells of a patient · 278 wordsNo dependents Claim 71A method of inducing hyperthermia in at least target cells of a patient · 282 wordsNo dependents

A method of inducing hyperthermia in at least target cells of a patient, comprising the steps of:

providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating a hyperthermia-inducing RF signal having at least one frequency for transmission via the transmission head;
providing antibodies or antibody fragments or other targeting moieties labeled with at least one particle of electrically conductive radiometal suitable for radiotherapy and characterized by targeting a target biomolecule of at least one of the target cells;
providing a reception head different from the transmission head;
introducing the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties into the patient;
waiting for at least some of the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties to bind to some of the target cells;
arranging the transmission head and the reception head on opposite sides of at least one body part of the patient containing the target cells in such a manner that the RF signal transmitted via the transmission head to the reception head passes through and warms at least the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties bound to target cells;
transmitting the RF signal via the transmission head to the reception head, thereby warming the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties bound to target cells;
and
receiving with the reception head at least a portion of the RF signal that passed through the patient.

6 more elements

A method of inducing hyperthermia in at least target cells of a patient, comprising the steps of:

providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating a hyperthermia-inducing RF signal having at least the one frequency for transmission via the transmission head;
providing biomolecules labeled with at least one radionuclide and characterized by targeting a target biomolecule of at least one of the target cells;
providing a reception head different from the transmission head;
introducing the radionuclide-labeled biomolecules into the patient;
providing targeted RF absorption enhancers characterized by binding to the target cells to thereby increase heating of target cells responsive to the RF signal by interaction between the RF signal and the targeted RF absorption enhancer;
introducing the targeted RF absorption enhancers into the patient;
waiting for at least some of the radionuclide-labeled biomolecules to bind to some of the target cells;
arranging the transmission head and the reception head on opposite sides of at least one body part of the patient containing the target cells in such a manner that the RF signal transmitted via the transmission head to the reception head passes through and warms at least the radionuclide-labeled biomolecules and targeted RF absorption enhancers bound to target cells;
transmitting the RF signal via the transmission head to the reception head, thereby warming the radionuclide-labeled biomolecules and targeted RF absorption enhancers bound to target cells;
and
receiving with the reception head at least a portion of the RF signal that passed through the patient;
and
wherein the targeted RF absorption enhancers comprise at least one targeting moiety bound to at least one particle of electrically conductive metal.

10 more elements

A method of inducing hyperthermia in at least target cells of a patient, comprising the steps of:

providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating a hyperthermia-inducing RF signal having at least one frequency for transmission via the transmission head;
providing antibodies or antibody fragments or other targeting moieties labeled with at least one particle of electrically conductive radiometal suitable for radiotherapy and characterized by targeting a target biomolecule of at least one of the target cells;
providing a reception head different from the transmission head;
introducing the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties into the patient;
waiting for at least some of the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties to bind to some of the target cells;
arranging the transmission head and the reception head on opposite sides of at least one body part of the patient containing the target cells in such a manner that the RF signal transmitted via the transmission head to the reception head passes through and warms at least the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties bound to target cells;
transmitting the RF signal via the transmission head to the reception head, thereby warming the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties bound to target cells;
and
receiving with the reception head at least a portion of the RF signal that gassed through the patient;
and
wherein the particle of electrically conductive radiometal is partially depleted when the RF signal transmitted via the transmission head to the reception head.

8 more elements

A method of inducing hyperthermia in at least target cells of a patient, comprising the steps of:

providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating a hyperthermia-inducing RF signal having at least the one frequency for transmission via the transmission head;
providing biomolecules labeled with at least one radionuclide and characterized by targeting a target biomolecule of at least one of the target cells;
providing a reception head different from the transmission head;
introducing the radionuclide-labeled biomolecules into the patient;
providing targeted RF absorption enhancers characterized by binding to the target cells to thereby increase heating of target cells responsive to the RF signal by interaction between the RF signal and the targeted RF absorption enhancer;
introducing the targeted RF absorption enhancers into the patient;
waiting for at least some of the radionuclide-labeled biomolecules to bind to some of the target cells;
arranging the transmission head and the reception head on opposite sides of at least one body part of the patient containing the target cells in such a manner that the RF signal transmitted via the transmission head to the reception head passes through and warms at least the radionuclide-labeled biomolecules and targeted RF absorption enhancers bound to target cells;
transmitting the RF signal via the transmission head to the reception head, thereby warming the radionuclide-labeled biomolecules and targeted RF absorption enhancers bound to target cells;
and
receiving with the reception head at least a portion of the RF signal that passed through the patient;
and
wherein the targeted RF absorption enhancers comprise at least one targeting moiety bound to at least one particle of electrically conductive metal;
and
wherein the particle of electrically conductive radiometal is partially depleted when the RF signal transmitted via the transmission head to the reception head.

12 more elements

A method of inducing hyperthermia in at least target cells of a patient, comprising the steps of:

providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating a hyperthermia-inducing RF signal having at least the one frequency for transmission via the transmission head;
providing antibodies or antibody fragments or other targeting moieties labeled with at least one particle of electrically conductive radiometal and characterized by targeting a target biomolecule of at least one of the target cells;
providing a reception head different from the transmission head;
introducing the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties into the patient;
waiting for at least some of the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties to bind to some of the target cells;
arranging the transmission head and the reception head on opposite sides of at least one body part of the patient containing the target cells in such a manner that the RF signal transmitted via the transmission head to the reception head passes through and warms at least the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties bound to target cells;
transmitting the RF signal via the transmission head to the reception head, thereby warming the radiotherapy-suitable radiometal-labeled monoclonal antibodies bound to target cells;
and
receiving with the reception head at least a portion of the RF signal that passed through the patient.

6 more elements

A method of inducing hyperthermia in at least target cells of a patient, comprising the steps of:

providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating a hyperthermia-inducing RF signal having at least one frequency for transmission via the transmission head;
providing antibodies or antibody fragments or other targeting moieties labeled with at least one particle of electrically conductive radiometal suitable for radiotherapy and characterized by targeting a target biomolecule of at least one of the target cells;
providing a reception head different from the transmission head;
introducing the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties into the patient;
waiting for at least some of the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties to bind to some of the target cells;
arranging the transmission head and the reception head on opposite sides of at least one body part of the patient containing the target cells in such a manner that the RF signal transmitted via the transmission head to the reception head passes through and warms at least the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties bound to target cells;
transmitting the RF signal via the transmission head to the reception head, thereby warming the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties bound to target cells;
and
receiving with the reception head at least a portion of the RF signal that passed through the patient;
and
wherein the heating the particles of electrically conductive radiometal is caused by a field consisting essentially of the RF field that is being generated from the RF signal between the transmission head and the reception head.

8 more elements

A method of inducing hyperthermia in at least target cells of a patient, comprising the steps of:

providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating a hyperthermia-inducing RF signal having at least one frequency for transmission via the transmission head;
providing antibodies or antibody fragments or other targeting moieties labeled with at least one particle of electrically conductive radiometal suitable for radiotherapy and characterized by targeting a target biomolecule of at least one of the target cells;
providing a reception head different from the transmission head;
introducing the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties into the patient;
waiting for at least some of the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties to bind to some of the target cells;
arranging the transmission head and the reception head on opposite sides of at least one body cart of the patient containing the target cells in such a manner that the RF signal transmitted via the transmission head to the reception head passes through and warms at least the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties bound to target cells;
transmitting the RF signal via the transmission head to the reception head, thereby warming the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties bound to target cells;
and
receiving with the reception head at least a portion of the RF signal that passed through the patient;
and
wherein the heating the particles of electrically conductive radiometal is caused by a field consisting solely of the RF field that is being generated from the RF signal between the transmission head and the reception head.

8 more elements

A method of inducing hyperthermia in at least target cells of a patient, comprising the steps of:

providing an RF transmitter haying an RF generator in circuit communication with a transmission head, the RF generator capable of generating a hyperthermia-inducing RF signal having at least one frequency for transmission via the transmission head;
providing antibodies or antibody fragments or other targeting moieties labeled with at least one particle of electrically conductive radiometal suitable for radiotherapy and characterized by targeting a target biomolecule of at least one of the target cells;
providing a reception head different from the transmission head;
introducing the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties into the patient;
waiting for at least some of the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties to bind to some of the target cells;
arranging the transmission head and the reception head on opposite sides of at least one body part of the patient containing the target cells in such a manner that the RF signal transmitted via the transmission head to the reception head passes through and warms at least the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties bound to target cells;
transmitting the RF signal via the transmission head to the reception head, thereby warming the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties bound to target cells;
and
receiving with the reception head at least a portion of the RF signal that passed through the patient;
and
wherein at least target cells bound to the antibodies or antibody fragments or other targeting moieties labeled with at least one particle of electrically conductive radiometal are killed or damaged by the heating of the particles of electrically conductive radiometal.

8 more elements

A method for inducing hyperthermia in target cells in a patient, comprising:

introducing into the patient RF absorption enhancers capable of selectively binding to the target cells and further capable of generating sufficient heat to kill or damage the bound target cells by heat generated solely by the application of an RF field generated by an RF signal between a transmission head and a reception head that is different from the transmission head;
arranging the transmission and reception heads on opposite sides of a portion of the patient for treatment;
and
irradiating a portion of the patient between the transmission and reception heads containing RF absorption enhancers with an RF field to kill or damage the target cells by hyperthermia from the heat generated by the RF absorption enhancers;
and
wherein the targeted RF absorption enhancers introduced into the patient comprise at least one targeting moiety bound to at least one particle of electrically conductive radiometal suitable for radiotherapy.

3 more elements

A method for inducing hyperthermia in target cells in a patient, comprising:

introducing into the patient RF absorption enhancers capable of selectively binding to the target cells and further capable of generating sufficient heat to kill or damage the bound target cells by heat generated solely by the application of an RF field generated by an RF signal between a transmission head and a reception head that is different from the transmission head;
arranging the transmission and reception heads on opposite sides of a portion of the patient for treatment;
and
irradiating a portion of the patient between the transmission and reception heads containing RF absorption enhancers with an RF field to kill or damage the target cells by hyperthermia from the heat generated by the RF absorption enhancers;
and
wherein the targeted RF absorption enhancers introduced into the patient comprise at least one targeting moiety bound to at least one particle of electrically conductive radiometal suitable for radiotherapy;
and
wherein the patient is irradiated with a field consisting essentially of the RF field between the transmission and reception heads.

5 more elements

A method for inducing hyperthermia in target cells in a patient, comprising:

introducing into the patient RF absorption enhancers capable of selectively binding to the target cells and further capable of generating sufficient heat to kill or damage the bound target cells by heat generated solely by the application of an RF field generated by an RF signal between a transmission head and a reception head that is different from the transmission head;
arranging the transmission and reception heads on opposite sides of a portion of the patient for treatment;
and
irradiating a portion of the patient between the transmission and reception heads containing RF absorption enhancers with an RF field to kill or damage the target cells by hyperthermia from the heat generated by the RF absorption enhancers;
and
wherein the targeted RF absorption enhancers introduced into the patient comprise at least one targeting moiety bound to at least one particle of electrically conductive radiometal suitable for radiotherapy;
and
wherein the patient is irradiated solely with the RF field between the transmission and reception heads.

5 more elements

A method for inducing hyperthermia in target cells in a patient, comprising:

introducing into the patient RF absorption enhancers capable of selectively binding to the target cells and further capable of generating sufficient heat to kill or damage the bound target cells by heat generated solely by the application of an RF field generated by an RF signal between a transmission head and a reception head that is different from the transmission head;
arranging the transmission and reception heads on opposite sides of a portion of the patient for treatment;
and
irradiating a portion of the patient between the transmission and reception heads containing RF absorption enhancers with an RF field to kill or damage the target cells by hyperthermia from the heat generated by the RF absorption enhancers;
and
wherein the targeted RF absorption enhancers introduced into the patient comprise at least one targeting moiety bound to at least one particle of electrically conductive radiometal suitable for radiotherapy;
and
wherein the RF absorption enhancers are excited to generate heat for killing or damaging the target cells by hyperthermia solely by irradiation with a field consisting essentially of the RF field between the transmission and reception heads.

5 more elements

A method for inducing hyperthermia in target cells in a patient, comprising:

introducing into the patient RF absorption enhancers capable of selectively binding to the target cells and further capable of generating sufficient heat to kill or damage the bound target cells by heat generated solely by the application of an RF field generated by an RF signal between a transmission head and a reception head that is different from the transmission head;
arranging the transmission and reception heads on opposite sides of a portion of the patient for treatment;
and
irradiating a portion of the patient between the transmission and reception heads containing RF absorption enhancers with an RF field to kill or damage the target cells by hyperthermia from the heat generated by the RF absorption enhancers;
and
wherein the targeted RF absorption enhancers introduced into the patient comprise at least one targeting moiety bound to at least one particle of electrically conductive radiometal suitable for radiotherapy;
and
wherein the RF absorption enhancers are excited to generate heat for killing or damaging the target cells by hyperthermia solely by irradiation with the RF field between the transmission and reception heads.

5 more elements

A method of inducing hyperthermia in at least target cells of a patient, comprising the steps of:

providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating a hyperthermia-inducing RF signal having at least the one frequency for transmission via the transmission head;
providing antibodies or antibody fragments or other targeting moieties labeled with at least one particle of electrically conductive radiometal and characterized by targeting a target biomolecule of at least one of the target cells;
providing a reception head different from the transmission head;
introducing the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties into the patient;
waiting for at least some of the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties to bind to some of the target cells;
arranging the transmission head and the reception head on opposite sides of at least one body part of the patient containing the target cells in such a manner that the RF signal transmitted via the transmission head to the reception head passes through and warms at least the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties bound to target cells;
transmitting the RF signal via the transmission head to the reception head, thereby warming the radiotherapy-suitable radiometal-labeled monoclonal antibodies bound to target cells;
and
receiving with the reception head at least a portion of the RF signal that passed through the patient;
and
wherein the heating the particles of electrically conductive radiometal is caused by a field consisting essentially of the RF field that is being generated from the RF signal between the transmission head and the reception head.

8 more elements

A method of inducing hyperthermia in at least target cells of a patient, comprising the steps of:

providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating a hyperthermia-inducing RF signal having at least the one frequency for transmission via the transmission head;
providing antibodies or antibody fragments or other targeting moieties labeled with at least one particle of electrically conductive radiometal and characterized by targeting a target biomolecule of at least one of the target cells;
providing a reception head different from the transmission head;
introducing the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties into the patient;
waiting for at least some of the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties to bind to some of the target cells;
arranging the transmission head and the reception head on opposite sides of at least one body part of the patient containing the target cells in such a manner that the RF signal transmitted via the transmission head to the reception head passes through and warms at least the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties bound to target cells;
transmitting the RF signal via the transmission head to the reception head, thereby warming the radiotherapy-suitable radiometal-labeled monoclonal antibodies bound to target cells;
and
receiving with the reception head at least a portion of the RF signal that passed through the patient;
and
wherein the heating the particles of electrically conductive radiometal is caused by a field consisting solely of the RF field that is being generated from the RF signal between the transmission head and the reception head.

8 more elements

A method of inducing hyperthermia in at least target cells of a patient, comprising the steps of:

providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating a hyperthermia-inducing RF signal having at least the one frequency for transmission via the transmission head;
providing antibodies or antibody fragments or other targeting moieties labeled with at least one particle of electrically conductive radiometal and characterized by targeting a target biomolecule of at least one of the target cells;
providing a reception head different from the transmission head;
introducing the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties into the patient;
waiting for at least some of the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties to bind to some of the target cells;
arranging the transmission head and the reception head on opposite sides of at least one body part of the patient containing the target cells in such a manner that the RF signal transmitted via the transmission head to the reception head passes through and warms at least the radiotherapy-suitable radiometal-labeled antibodies or antibody fragments or other targeting moieties bound to target cells;
transmitting the RF signal via the transmission head to the reception head, thereby warming the radiotherapy-suitable radiometal-labeled monoclonal antibodies bound to target cells;
and
receiving with the reception head at least a portion of the RF signal that passed through the patient;
and
wherein at least target cells bound to the antibodies or antibody fragments or other targeting moieties labeled with at least one particle of electrically conductive radiometal are killed or damaged by the heating of the particles of electrically conductive radiometal.

8 more elements

Dependencies are inferred from the claim text.

Facts

Application: 11/050,478Filed 3 Feb 2005 · continuation in part
Priority: 7 May 2004
Published: US 2005/0251233 A18 Dec 2005
Granted: 1 Dec 2009
Term ends: Not estimatedThe source records don’t support an estimate.

Classification10 codes

A61K 41/0052
Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations: thermotherapy;…
A61N 1/403
Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals: for thermotherapy, e.g. hyperthermia
A61N 1/406
For thermotherapy, e.g. hyperthermia: using implantable thermoseeds or injected particles for localized hyperthermia
A61N 5/1001
X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy: using radiation sources introduced into or applied onto the body; brachytherapy

Family

Application60/569,348Us provisional application · filed 7 May 2004
Application10/969,477Parent of this continuation-in-part · filed 20 Oct 2004
US 2005/0273143 A1Pre-grant publication · published 8 Dec 2005
US 2005/0251233 A1Published application
US 7,627,381 B2This patent

From the US filing history. Foreign family members aren’t listed.

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