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US 7,627,153 B2Granted
Repositioning inaccuracies in an automated imaging system
AssigneeCarl Zeiss MicroImaging GmbH
InventorsCynthia B. Perz, Robert T. Ellis
Life of this patent
Estimating the term…
Abstract
Systems and techniques for reducing repositioning inaccuracies in imaging systems. Initial image data and positional information is received and cross-correlated with additional image data and positional information. An offset may be determined based on the cross-correlation.
Claims23
A method comprising:
- receiving initial image data corresponding to a first sample area of a biological sample;
- receiving initial positional information for the initial image data, the initial positional information indicative of an initial relative position of the first sample area with respect to an imaging system that obtained the data;
- using a positioner to reposition the first sample area with respect to the imaging system;
- receiving additional image data using the imaging system after repositioning the first sample area with respect to the imaging system;
- receiving additional positional information for the additional image data, the additional positional information indicative of a re-positioned relative position of the first sample area with respect to the imaging system;
- cross-correlating at least a portion of the initial image data and the additional image data using the associated initial image data, initial positional information, additional image data, and additional positional information;
- and determining an offset based on the cross-correlating.
4 more elements
An article comprising a computer-readable storage medium storing instructions operable to cause one or more machines to perform operations comprising:
- receive initial image data obtained using an imaging system, the initial image data corresponding to a first sample area of a biological sample;
- receive initial positional information for the initial image data, the initial positional information indicative of an initial relative position of the first sample area with respect to the imaging system;
- receive additional image data using the imaging system, the additional image data obtained after repositioning the first sample area with respect to the imaging system;
- receive additional positional information for the additional image data, the additional positional information indicative of a re-positioned relative position of the first sample area with respect to the imaging system;
- cross-correlate at least a portion of the initial image data and the additional image data using the associated initial image data, initial positional information, additional image data, and additional positional information;
- and determine an offset based on the cross-correlating.
3 more elements
An imaging system comprising:
- a positioner configured to position a sample relative to imaging optics;
- a controller in communication with the positioner, the controller configured to generate a signal to control the position of the sample relative to the imaging optics;
- an image processing system, the image processing system configured to:
- receive initial positional information for the initial image data, the initial positional information indicative of an initial relative position of the first sample area with respect to the imaging system;
- receive additional image data using the imaging system, the additional image data obtained after repositioning the first sample area with respect to the imaging system;
- receive additional positional information for the additional image data, the additional positional information indicative of a re-positioned relative position of the first sample area with respect to the imaging system;
- cross-correlate at least a portion of the initial image data and the additional image data using the associated initial image data, initial positional information, additional image data, and additional positional information;
- and determine an offset based on the cross-correlating.
5 more elements
Dependencies are inferred from the claim text.