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US 7,626,704 B2Granted
Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
AssigneePacific Biosciences of California, Inc.
InventorsPaul Lundquist, Denis Zaccarin, Yves Lacroix, Mark Maxham, Mathieu Foquet, Stephen Turner
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Abstract
Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.
Claims10
A system for monitoring optical signals, comprising:
- a substrate having at least a first source of optical signals disposed thereon;
- an optical train positioned to receive optical signals from the at least first source of optical signals and image the optical signals onto an imaging detector;
- an imaging detector comprising a plurality of pixels, the detector positioned to receive the image of the optical signals on a first set of pixels in the plurality of pixels;
- and
- a processor programmed to process signal data from the detector to monitor the optical signals;
- wherein at least one of the detector or processor are configured to process signal data from the first set of pixels in a first data process and data from a second set of pixels in the plurality of pixels different from the first set of pixels in a second data process different from the first data process;
- and wherein the first data process comprises subjecting the signal data from the first set of pixels to a gain protocol to amplify the signal data and wherein the second data process does not include subjecting signal data from the second set of pixels to the gain protocol to amplify the signal data.
4 more elements
Dependencies are inferred from the claim text.