Glycerophosphoinositol derivatives as modulators of cytosolic A2 phospholipase

Method of treatment of inflammation comprising the administration, to a patient in need thereof, of a compound of formula (I):

• wherein:
• R1′, R2′, R2, R3, R4, R5, R6 is each, independently,
• (a) H;
• or
• (b) C(O)A, an acylic mono-carboxylic acid or di-carboxylic acid, where A is a radical selected from the group consisting of
• (i) a saturated or unsaturated, straight or branched, alkyl radical having from 1 to no more than 8 carbon atoms and from 0 to no more than 4 double bonds;
• (ii) a mono- or polycyclic alkyl or alkenyl radical and
• (iii) an aryl, arylalkyl or heterocyclic radical having one or more heteroatoms;
• wherein said radical is unsubstituted or substituted with one or more groups selected from the group consisting of keto, hydroxyl, acylamidic, halogen, mercapto, alkylthio or alkyldithio, —COOH, wherein the —COOH is salified to form a —COOM salt, or unsalified, and
• wherein M is the cation of a pharmaceutically acceptable inorganic element or a cation of a pharmacologically acceptable organic base, both having a valence n+, wherein n is 1 or 2 or 3, and;
• X and Y are O.