Method, system and computer program product for technical management and biocontrol of disease in animal production systems

A computer-readable medium carrying one or more sequences of one or more instructions for controlling disease in aquatic animals at an end user location, the one or more sequences of one or more instructions including instructions which, when executed by one or more processors, cause the one or more processors to perform the steps of:

• (a) testing a range of candidates including at least one of:
• (i) Bacillus species, (ii) Bacillus strains, (iii) species of beneficial bacteria (iv) strains of beneficial bacteria and (v) strains of beneficial bacterial viruses, against samples including at least one of pathogenic Vibrio, Gram negative pathogenic bacteria and Gram positive pathogenic bacteria taken from an end user location;
• performing the step of selecting one or more of the candidates that inhibit and attack at least one of the samples by at least one of in situ antibiotic production, competitive exclusion, and production of enzymes that degrade quorum sensing molecules,
• (b) testing a range of quorum sensing inhibitor compounds against the samples;
• and
• (c) performing the steps (a) and (b) for the end user location, including one of a country, major region and individual end user location, to determine microbial strain composition based on the selected candidate and/or quorum sensing inhibitor compounds and the tested range of quorum sensing inhibitor compounds to formulate a product and target microbial technology for use in bio-control of disease specific to the end user location.

A system for controlling disease in aquatic animals at an end user location, comprising:

• (a) means for testing a range of candidates including at least one of:
• (i) Bacillus species, (ii) Bacillus strains, (iii) species of beneficial bacteria (iv) strains of beneficial bacteria and (v) strains of beneficial bacterial viruses, against samples including at least one of pathogenic Vibrio, Gram negative pathogenic bacteria and Gram positive pathogenic bacteria taken from an end user location;
• means for selecting one or more of the candidates that inhibit and attack at least one of the samples by at least one of in situ antibiotic production, competitive exclusion, and production of enzymes that degrade quorum sensing molecules,
• (b) means for testing a range of quorum sensing inhibitor compounds against the samples;
• and
• (c) means for performing (a) and (b) for the end user location, including one of a country, major region and individual end user location, to determine microbial strain composition based on the selected candidate and/or quorum sensing inhibitor compounds and the tested range of quorum sensing inhibitor compounds to formulate a product and target microbial technology for use in bio-control of disease specific to the end user location.

A system configured to control disease in aquatic animals at an end user location, comprising:

• (a) a technology deployer configured to test a range of candidates including at least one of:
• (i) Bacillus species, (ii) Bacillus strains, (iii) species of beneficial bacteria (iv) strains of beneficial bacteria and (v) strains of beneficial bacterial viruses, against samples including at least one of pathogenic Vibrio, Gram negative pathogenic bacteria and Gram positive pathogenic bacteria taken from an end user location;
• the technology deployer further configured to perform the step of selecting one or more of the candidates that inhibit and attack at least one of the samples by direct inhibition of at least one of in situ antibiotic production, competitive exclusion, and production of enzymes that degrade quorum sensing molecules, and
• (b) testing a range of quorum sensing inhibitor compounds against the samples,
• wherein the technology deployer is further configured to perform (a) and (b) at the end user location, including one of a country, major region and individual end user location, to determine microbial strain composition based on the selected candidate and/or quorum sensing inhibitor compounds and the tested range of quorum sensing inhibitor compounds to formulate a product and target microbial technology for use in bio-control of disease specific to the end user location.