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US 7,622,711 B2Granted
Mass spectrometer
AssigneeMicromass UK Limited
InventorsJason Lee Wildgoose, Steven Derek Pringle, Kevin Giles, Robert Harold Bateman
Life of this patent
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Abstract
A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator (3) arranged upstream of a collision or fragmentation cell (5). Ions are separated according to their ion mobility within the ion mobility spectrometer or separator (3). The kinetic energy of the ions exiting the ion mobility spectrometer or separator (3) is increased substantially linearly with time in order to optimize the fragmentation energy of ions as they enter the collision or fragmentation cell (5).
Claims46
A mass spectrometer comprising:
- an ion mobility spectrometer or separator, said ion mobility spectrometer or separator being arranged and adapted to separate ions according to their ion mobility;
- a fragmentation device;
- and
- acceleration means arranged and adapted to accelerate, into the fragmentation device, first ions emerging from said ion mobility spectrometer or separator at a time t1 so that they obtain a first kinetic energy E1 selected to cause fragmentation of substantially all of the first ions that enter the fragmentation device, and to accelerate, into the fragmentation device, second different ions emerging from said ion mobility spectrometer or separator at a second later time t2 so that they obtain a second different kinetic energy E2 selected to cause fragmentation of substantially all of the second ions that enter the fragmentation device.
1 more element
A mass spectrometer comprising:
- an ion mobility spectrometer or separator, said ion mobility spectrometer or separator being arranged and adapted to separate ions according to their ion mobility;
- a fragmentation device;
- and
- acceleration means arranged and adapted to accelerate, into the fragmentation device, first ions emerging from said ion mobility spectrometer or separator at a time t1 through a first potential difference V1 selected to cause fragmentation of substantially all of the first ions that enter the fragmentation device, and to accelerate, into the fragmentation device, second different ions emerging from said ion mobility spectrometer or separator at a second later time t2 through a second different potential difference V2 selected to cause fragmentation of substantially all of the second ions that enter the fragmentation device.
1 more element
A method of mass spectrometry comprising:
- separating ions according to their ion mobility in an ion mobility spectrometer or separator;
- accelerating, towards a fragmentation device, first ions emerging from said ion mobility spectrometer or separator at a time t1 so that they obtain a first kinetic energy E1 selected to cause fragmentation of substantially all of the first ions that enter the fragmentation device;
- accelerating, towards the fragmentation device, second different ions emerging from said ion mobility spectrometer or separator at a second later time t2 so that they obtain a second different kinetic energy E2 selected to cause fragmentation of substantially all of the second ions that enter the fragmentation device;
- and
- fragmenting substantially all of said first and second ions in the fragmentation device.
2 more elements
A method of mass spectrometry comprising:
- separating ions according to their ion mobility in an ion mobility spectrometer or separator;
- accelerating, towards a fragmentation device, first ions emerging from said ion mobility spectrometer or separator at a time t1 through a first potential difference V1 selected to cause fragmentation of substantially all of the first ions that enter the fragmentation device;
- accelerating, towards the fragmentation device, second different ions emerging from said ion mobility spectrometer or separator at a second later time t2 through a second different potential difference V2 selected to cause fragmentation of substantially all of the second ions that enter the fragmentation device;
- and
- fragmenting substantially all of said first and second ions in the fragmentation device.
2 more elements
Dependencies are inferred from the claim text.