Methods and compositions for providing tolerance to multiple herbicides

A method for controlling weeds in an area of cultivation comprising

• a) planting the area with crop seeds or plants which comprise
• i) a first polynucleotide encoding a polypeptide that can confer tolerance to glyphosate operably linked to a promoter active in a plant;
• and,
• ii) a second polynucleotide encoding an ALS inhibitor-tolerant polypeptide operably linked to a promoter active in a plant;
• b) applying to the crop, crop part, weed or area of cultivation thereof a combination of herbicides comprising at least an effective amount of a first and a second ALS inhibitor, wherein
• i) the effective amount of the combination of herbicides controls weeds;
• ii) the effective amount of the first ALS inhibitor is not tolerated by the crop when applied alone when compared to a control crop that has not been exposed to the first ALS inhibitor;
• and,
• iii) the effective amount of the second ALS inhibitor is sufficient to produce a safening effect, wherein said safening effect provides an increase in crop tolerance upon the application of the first and the second ALS inhibitor when compared to the crop tolerance when the first ALS inhibitor is applied alone.