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US 7,622,586 B2Granted
Opiate intermediates and methods of synthesis
AssigneeMallinckrodt Inc.
InventorsPeter Xianqi Wang, Frank W. Moser, Gary L. Cantrell
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Abstract
Novel opiate intermediate compositions and methods of synthesis that include changing the substitution pattern on the aromatic ring of the pre-Grewe intermediate are provided.
Claims3
A method comprising reacting a compound of Formula 12 with at least one reducing agent in a solvent including at least one alcohol to form a compound of Formula 13, and halogenating the compound of Formula 13 to form a compound of Formula 11:
- wherein:
- X is a halogen;
- R is H, alkyl, acyl, aryl, formyl, COR″, COOR″, benzyl, or sulfonamide;
- R′ is alkyl, aryl or acyl;
- and, R″ is alkyl or aryl.
2 more elements
Dependencies are inferred from the claim text.