Hetero isonipecotic modulators of vanilloid VR1 receptor

A compound of formula (I)

• wherein
• is thiomorpholin-4-yl;
• Y is bonded to
• at a substitutable atom and is independently selected from the group consisting of hydrogen;
• hydroxyl;
• R1;
• R1O—;
• R1S—;
• CF3O—;
• R1S(O)—;
• R1SO2—;
• —LCOX;
• C6-10aryl;
• n is an integer from 0 to 4;
• Ar is phenyl;
• naphthyl;
• a 5-6 membered heteroaryl ring selected from the group consisting of furan, imidazole, isothiazole, isoxazole, oxadiazole, oxazole, pyran, pyrazine, pyrazole, pyridazine, pyrrole, tetrazole, thiadiazole, triazine, and triazole;
• or a fused 5,6 or 6,6 heteroaryl selected from the group consisting of benzimidazole, benzisoxazole, benzofiaran, benzoxazole, benzthiazole, benzothiophene, cinnoline, indazole, indole, indoline, indolizine, isobenzofiaran, isoindole, isoindoline, isoquinoline, naphthyridine, pthalazine, pteridine, pyrrolizine, quinoline, and quinolizine;
• R1 is C1-10alkyl;
• L is —NH—, a direct bond, —O—, or —CH2—;
• X is H, R1, HO, R1O—, R1S—, —NH2, R1NH—, or (R1)2N—;
• and enantiomers, diastereomers, tautomers, solvates, and pharmaceutically acceptable salts thereof.