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US 7,622,574 B2Granted
IL-14α RNA inhibitors and antibodies to IL-14α for treatment of autoimmune diseases and lymphomas
AssigneeThe Research Foundation of State University of New York
InventorsJulian L. Ambrus, Jr., Long Shen, Richard Ford, Chongjie Zhang
Life of this patent
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Abstract
Provided are antisense poly-2′-O-(2,4-dinitrophenyl)oligoribonucleotides which are complementary to the IL-14α gene and/or transcribed IL-14α mRNA. Also provided are monoclonal antibodies reactive with discreet IL-14α peptides. The oligoribonucleotides and monoclonal antibodies are useful in inhibiting the growth of lymphocytes.
Claims7
An isolated oligoribonucleotide consisting of SEQ ID NO:1, SEQ ID NO:2 or SEQ ID NO:3,
- wherein the ribose residue of at least one nucleotide in the oligoribonucleotide is protected at the 2′-O-position by 2,4-dinitrophenyl (DNP).
Dependencies are inferred from the claim text.