Multidimensional organization of heteromolecules by robust DNA motifs
AssigneeNew York University
InventorsNadrian C. Seeman, Jiwen Zheng, Pamela E. Constantinou
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Abstract
Two dimensional polynucleic acid arrays are assembled from robust nucleic acid motifs as polygonal units. The polygonal units in an array have edges composed of nucleic acid multi-crossover domains and are joined together by double cohesion of adjacent polygonal units. A subset of polygonal units in the array have a nanoparticle or pendant molecule attached to an end of one edge of each polygonal unit within this subset.
Claims20
A two dimensional polynucleic acid array of polygonal units linked together by complementary double cohesive ends, comprising a plurality of polygonal units, wherein:
- each of said polygonal units has, as edges, parallel helices of connected nucleic acid multi-crossover domains along their helix axes;
- each of at least two said edges of each of said polygonal units has ends with two parallel double helices;
- each of said two parallel double helices terminate in a cohesive end to provide a double cohesive end at each end of said at least two edges, whereby said double cohesive end of one edge of a polygonal unit is cohered to a complementary double cohesive end of an adjacent polygonal unit in the array to form an extended edge linking together two adjacent polygonal units;
- and
- at least one edge, which is different from said at least two edges, of a subset of said polygonal units has at least one end which is attached to a nanoparticle or pendant molecule.
Dependencies are inferred from the claim text.