Prostate stem cell antigen (PSCA) variants and subsequences thereof
AssigneeAgensys, Inc.
InventorsWangmao Ge, Pia M. Challita-Eid, Arthur B. Raitano, Aya Jakobovits
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Abstract
PSCA and its encoded protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, propylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
Claims4
An isolated polynucleotide, wherein the polynucleotide is selected from the group consisting of:
- a nucleotide sequence that encodes a PSCA protein comprising the amino acid sequence of SEQ ID NO:
- 6547, 6548, 6549, 6550, 6551, 6552, 6553, or 6554.
Dependencies are inferred from the claim text.