Monoclonal antibody specific for CD43 epitope
AssigneeDinona Inc.
InventorsSeong-Hoe Park, Kyeong-Cheon Jung, Eun-Young Choi, Seong-Pyo Park
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Abstract
The present invention relates to a CD43 epitope expressed on human acute leukemia and lymphoblastic lymphoma cells and its use. More particularly, the present invention relates to a CD43 epitope expressed on human acute leukemia, lymphoblastic lymphoma cells, but not on mature hematopoietic cells, hematopoietic stem cells and non-hematopoietic cells, and to its diagnostic and therapeutic application on acute leukemia and lymphoblastic lymphoma.
Claims25
A monoclonal antibody, or an antigen-binding fragment thereof, which specifically binds to an epitope of CD43, wherein the epitope consists of an amino acid sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 2, wherein the antibody is in purified form, and wherein the antibody is not an antibody produced by the hybridoma deposited as KCLRF-BP-00010.
A monoclonal antibody, or an antigen-binding fragment thereof, which binds to a peptide consisting of an amino acid sequence of SEQ ID NO:
- 1 or SEQ ID NO:2, wherein the antibody is in purified form and the antibody is not an antibody produced by the hybridoma deposited as KCLRF-BP-00010.
Dependencies are inferred from the claim text.