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US 7,622,556 B2Granted
Modified cytokines for use in cancer therapy
AssigneeFondazione Centro San Raffaele Del Monte Tabor
InventorAngelo Corti
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Abstract
Cytokine derivatives capable of homing the tumoral vessels and the antigen presenting cells and the use thereof as antitumoral agents.
Claims18
A conjugation product between TNF and a ligand of the CD13 receptor, wherein the ligand is a peptide comprising the NGR motif.
A cDNA encoding for TNF and bearing a 5′ or 3′ contiguous sequence encoding a ligand of the CD13 receptor, wherein the ligand is a peptide comprising the NGR motif.
Dependencies are inferred from the claim text.