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US 7,622,555 B2Granted
Cytokine antagonist molecules
AssigneeAres Trading S.A.
InventorsAndrew Robert Davids, Richard Joseph Fagan, Christopher Benjamin Phelps, Christine Power, Yolande Chvatchko, Ursula Boschert
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Abstract
This invention relates to a novel protein (INSP052), herein identified as an immunoglobulin domain-containing cell surface recognition molecule and to the use of this proteins and nucleic acid sequences from the encoding gene in the diagnosis, prevention and treatment of disease. The invention also relates to the identification of the extracellular domain of INSP052.
Claims18
An isolated polypeptide, which
- comprises the amino acid sequence as recited in SEQ ID NO:16 or SEQ ID NO:26,
- wherein the polypeptide functions as an antagonist of cytokine expression and/or secretion of a cytokine selected from the group consisting of TNF-α, IL-4 IL-2, IL-6, IL-5, and IL-10.
An isolated polypeptide, which consists of the amino acid sequence as recited in SEQ ID NO:16, SEQ ID NO:26, SEQ ID NO:20;
- or SEQ ID NO:22, wherein the polypeptide functions as an antagonist of cytokine expression and/or secretion of a cytokine selected from the group consisting of TNF-α, IL-4 and IL-2, IL-6, IL-5, and IL-10.
Dependencies are inferred from the claim text.