Human telomerase reverse transcriptase polypeptides
AssigneesGeron Corporation, The Regents of the University of Colorado
InventorsThomas R. Cech, Joachim Lingner, Toru Nakamura, Karen B. Chapman, Gregg B. Morin, Calvin B. Harley, William H. Andrews
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Abstract
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.
Claims4
An isolated immunogenic polypeptide that consists of 10 or more consecutive amino acids of SEQ. ID NO:2.
An isolated immunogenic polypeptide that consists of 8 or more consecutive amino acids of SEQ. ID NO:2.
A composition comprising an isolated polypeptide consisting of 8 or more consecutive amino acids of SEQ ID NO:2, wherein said composition elicits an adaptive immune response against human telomerase reverse transcriptase having the sequence of SEQ. ID NO:2.
A composition comprising an isolated polypeptide consisting of 10 or more consecutive amino acids of SEQ ID NO:2, wherein said composition elicits an adaptive immune response against human telomerase reverse transcriptase having the sequence of SEQ. ID NO:2.
Dependencies are inferred from the claim text.