Methods for manufacturing amino acid mimetic copolymers and use of same
AssigneeAbbott Laboratories
InventorStephen Pacetti
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Abstract
Biocompatible polymers are manufactured to include an amino acid mimetic monomer and one or more hydrophobic acrylate monomers. The amino acid mimetic monomers are selected to mimic the side chain of the amino acids asparagine or glutamine. The amino acid mimetic monomer can be a methacryloyl or acryloyl derivative of 2-hydroxyacetamide, 3-hydroxypropionamide, alaninamide, lactamide, or glycinamide. These amide functional groups offer the advantage of moderate hydrophilicity with little chemical reactivity. The amino acid mimetic monomer can be copolymerized with one or more hydrophobic acrylate monomers to obtain desired coating properties.
Claims20
A method for manufacturing a biocompatible copolymer, comprising:
- copolymerizing a plurality of acrylate monomers to yield a copolymer having the following formula,
- in which,
- the hydrophobic group is a straight chain, branched, unsaturated, or cyclic hydrocarbon of one to sixteen carbon atoms;
- the amino acid mimetic group is an acetamide, a propionamide, an alaninamide, a lactamide, or a glycinamide;
- R1 and R2 are independently a hydrogen or a methyl group;
- m is in a range from about 0.1 to about 0.995;
- and
- n is in a range from about 0.005 to about 0.9.
Dependencies are inferred from the claim text.