8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists

A compound of formula (I):

• wherein:
• R1 is selected from —ORa, —C(O)NRaRb, —NHS(O)2Rc, —NRaRb, —C(O)ORa, and —CH2OH;
• A is C1-4alkylenyl;
• R2 is C3-12cycloalkyl or C6-10aryl, wherein C3-12cycloalkyl and C6-10aryl are each optionally substituted with one —ORa, with one or two halo, with one or two C1-3alkyl substituted with two or three halo;
• or with one, two, three or four C1-3alkyl;
• G is C1-4alkylenyl;
• R3 is selected from hydrogen, —C(O)R4, —C(O)NHR5, —S(O)2Rc, and —S(O)2NRaRb;
• R4 is C3-6cycloalkyl or C1-6alkyl,
• wherein
• C3-6cycloalkyl is optionally substituted with one —ORa, and
• C1-6alkyl is optionally substituted with one or two substituents selected from —ORa, —C(O)ORa, —S(O)2R6, —C(O)NRaRb, —NRaRb, —NHC(O)NRaRb, —CN, C3-6cycloalkyl, and phenyl;
• or with one -D-(CH2)j—R7,
• wherein D is
• j is 1, 2, or 3, n is 1 or 2, and p is 1 or 2,
• R6 is C1-3alkyl optionally substituted with R7
• R7 is —C(O)ORa, —C(O)NRaRb, —NRaRb, or —NHC(O)NRaRb
• R5 is C1-6alkyl, benzo[1.3]dioxol, or —(CH2)q-phenyl,
• wherein phenyl is optionally substituted with one or two substituents selected from halo, —ORa, C1-3alkyl, and C1-3alkoxy, wherein C1-3alkyl, and C1-3alkoxy are optionally substituted with 2 or 3 halo, and
• q is 0, 1, or 2;
• Ra and Rb are each independently hydrogen or C1-4alkyl, and;
• Rc is C1-3alkyl;
• provided that when R2 is phenyl substituted at the 4 position, R3 is not —C(O)R4 wherein R4 is C1-4alkyl substituted with —C(O)ORa;
• or a pharmaceutically-acceptable salt thereof.