Selective androgen receptor modulators and methods of use thereof
AssigneeUniversity of Tennessee Research Foundation
InventorsJames T. Dalton, Duane D. Miller, Karen A. Veverka
Life of this patent
Estimating the term…
Abstract
This invention provides SARM compounds and their use in treating a variety of diseases or conditions in a subject, including, inter-alia, a muscle wasting disease and/or disorder or a bone-related disease and/or disorder.
Claims23
A method of treating a subject having a bone-related disorder, comprising the step of administering to said subject a SARM compound represented by a structure of formula (I), its pharmaceutically acceptable salt, or a combination thereof, or a composition comprising the same:
- wherein
- X is O;
- Z is NO2, CN, COR, or CONHR;
- Y is I, CF3, Br, Cl, F or Sn(R)3;
- Q is CN;
- T is OH, OR, —NHCOCH3, NHCOR or OC(O)R;
- R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3, aryl, phenyl, halogen, alkenyl or OH;
- and
- R1 is CH3, CH2F, CHF2, CH2CH3, or CF2CF3.
A method of increasing the strength of, or mass of a bone of a subject, or in promoting bone formation in a subject, comprising the step of administering to said subject a SARM compound represented by a structure of formula (I), its pharmaceutically acceptable salt, or any combination thereof, or a composition comprising the same:
- wherein
- X is O;
- Z is NO2, CN, COR, or CONHR;
- Y is I, CF3, Br, Cl, F or Sn(R)3;
- Q is CN;
- T is OH, OR, —NHCOCH3, NHCOR or OC(O)R;
- R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3, aryl, phenyl, halogen, alkenyl or OH;
- and
- R1 is CH3, CH2F, CHF2, CH2CH3, or CF2CF3.
A method in the intervention of osteoperosois or osteopenia, comprising the step of administering to said subject a SARM compound represented by a structure of formula (I), its pharmaceutically acceptable salt, or any combination thereof, or a composition comprising the same:
- wherein
- X is O;
- Z is NO2, CN, COR, or CONHR;
- Y is I, CF3, Br, Cl, F or Sn(R)3;
- Q is CN;
- T is OH, OR, —NHCOCH3, NHCOR or OC(O)R;
- R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3, aryl, phenyl, halogen, alkenyl or OH;
- and
- R1 is CH3, CH2F, CHF2, CH2CH3, or CF2CF3.
A method of treating, suppressing, inhibiting or reducing the incidence of a muscle wasting disorder in a subject comprising the step of administering to said subject a SARM compound represented by a structure of formula (I), its pharmaceutically acceptable salt, or any combination thereof, or a composition comprising the same:
- wherein
- X is O;
- Z is NO2, CN, COR, or CONHR;
- Y is I, CF3, Br, Cl, F or Sn(R)3;
- Q is CN;
- T is OH, OR, —NHCOCH3, NHCOR or OC(O)R;
- R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3, aryl, phenyl, halogen, alkenyl or OH;
- and
- R1 is CH3, CH2F, CHF2, CH2CH3, or CF2CF3.
A method in increasing muscle performance, muscle size, muscle strength, or any combination thereof in a subject comprising the step of administering to said subject a SARM compound represented by a structure of formula (I), its pharmaceutically acceptable salt, or any combination thereof, or a composition comprising the same:
- wherein
- X is O;
- Z is NO2, CN, COR, or CONHR;
- Y is I, CF3, Br, Cl, F or Sn(R)3;
- Q is CN;
- T is OH, OR, —NHCOCH3, NHCOR or OC(O)R;
- R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3, aryl, phenyl, halogen, alkenyl or OH;
- and
- R1 is CH3, CH2F, CHF2, CH2CH3, or CF2CF3.
A method in treating obesity or diabetes associated with a metabolic syndrome in a subject comprising the step of administering to said subject a SARM compound represented by a structure of formula (I), its pharmaceutically acceptable salt, or any combination thereof, or a composition comprising the same:
- wherein
- X is O;
- Z is NO2, CN, COR, or CONHR;
- Y is I, CF3, Br, Cl, F or Sn(R)3;
- Q is CN;
- T is OH, OR, —NHCOCH3, NHCOR or OC(O)R;
- R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3, aryl, phenyl, halogen, alkenyl or OH;
- and
- R1 is CH3, CH2F, CHF2, CH2CH3, or CF2CF3.
A method in promoting or speeding recovery following a surgical procedure, in a subject comprising the step of administering to said subject a SARM compound represented by a structure of formula (I), its pharmaceutically acceptable salt, or any combination thereof, or a composition comprising the same:
- wherein
- X is O;
- Z is NO2, CN, COR, or CONHR;
- Y is I, CF3, Br, Cl, F or Sn(R)3;
- Q is CN;
- T is OH, OR, —NHCOCH3, NHCOR or OC(O)R;
- R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3, aryl, phenyl, halogen, alkenyl or OH;
- and
- R1 is CH3, CH2F, CHF2, CH2CH3, or CF2CF3.
Dependencies are inferred from the claim text.