Back to results
US 7,622,497 B2Granted
Derivatives of gambogic acid and analogs as activators of caspases and inducers of apoptosis
AssigneeCytovia, Inc.
InventorsSui Xiong Cai, Songchun Jiang, Han-Zhong Zhang
Life of this patent
Estimating the term…
Abstract
The present invention is directed to novel derivatives of gambogic acid and analogs thereof. The present invention also relates to the discovery that novel derivatives of gambogic acid are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
Claims4
A compound selected from the group consisting of:
- 2-(Morpholin-4-yl)-ethyl gambogate;
- 2-Dimethylaminoethyl gambogate;
- N-[3-(4-Methyl-piperazin-1-yl)-propyl]gambogamide;
- N-(3-Morpholin-4-yl-propyl)gambogamide;
- Methyl 37,38-Dihydroxy-gambogate;
- Methyl 37,38-Dihydroxy-9,10-dihydro-10-morpholinyl-gambogate;
- Methyl 20-Ethylaldehyde-9,10-dihydro-10-morpholinyl-morellinate;
- N-(4-Azido-2,3,5,6-tetrafluoro-benzyl)gambogamide;
- N-(1,2-Dicarboxylethyl)gambogamide;
- and
- N-(4-Azidobenzohydrazide)gambogamide.
8 more elements
Dependencies are inferred from the claim text.