Method of enhancing lysosomal α-galactosidase A
AssigneeMount Sinai School of Medicine of New York University
InventorsJian-Qiang Fan, Satoshi Ishii
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Abstract
A method of enhancing the activity of lysosomal α-Galactosidase A (α-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related compounds.
Claims18
A method for enhancing the activity of a lysosomal α-galactosidase A in a mammalian cell, which comprises contacting the cell with an amount of 1-deoxygalactonojirimycin effective to enhance enzyme activity of lysosomal α-galactosidase A.
A method for treating Fabry disease, which comprises administering to an individual in need thereof an amount of 1-deoxygalactonojirimycin effective to enhance enzyme activity of a mutant lysosomal α-galactosidase A.
Dependencies are inferred from the claim text.