1-nitroacridine/tumor inhibitor compositions

A composition comprising at least one 1-nitroacridine, wherein said 1-nitroacridine is selected from the group consisting of 1-nitro-4-alkyl-9-hydroxyalkylaminoacridine, 1-nitro-4-alkyl-9-hydroxyalkylaminoacridine, 1-nitro-9-alkoxyalkylaminoacridine and 1-nitro-9-alkylcarboxyalkylaminoacridine and at least one substance that inhibits tumor vasculature or biochemical processes that affect new blood vessel growth.

A composition comprising (a) at least one 1-nitroacridine selected from the group consisting of 1-nitro-4-alkyl-9-hydroxyalkylaminoacridine, 1-nitro-4-alkoxy-9-hydroxyalkylaminoacridine, 1-nitro-9-alkylcarboxyalkylaminoacridine and 1-nitro-9-alkoxyalkylaminoacridine and (b) at least one tumor inhibitor substance selected from the group consisting of an antiangiogenic substance, a nucleic acid synthesis inhibitor and a cell cycle inhibitor.

A composition comprising (a) at least one 1-nitroacridine elected from the group consisting of 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine, 9-(2′-hydroxyethylamino)-7-methoxy-1-nitroacridine, 9-(2′-hydroxyethylamino)-7-methoxy-4-methyl-1-nitroacridine, 9-(2′-acetoxyethylamino)-1-nitroacridine, 9-(2′-propionoxyethylamino)-1-nitroacridine, 9-(3′-hydroxypropylamino)-7-methoxy-1-nitroacridine, 9-(3′-hydroxypropylamino)-4-methyl-1-nitroacridine, 9-(2′-acetoxyethylamino)-4-methyl-1-nitroacridine 9-(2′-propionoxyethylamino)-4-methyl-1-nitroacridine, 9-(3′-acetoxypropylamino)-4-methyl-1-nitroacridine, 9-(2′-propionoxypropylamino)-4-methyl-1-nitroacridine, 9- (2′-hydroxyethylamino)-4-methoxy-1-nitroacridine, 9-(3′-hydroxypropylamino)-4-methoxy-1-nitroacridine, 9-(4′-hydroxybutylamino)-4-methoxy-1-nitroacridine, 9-(4′-hydroxybutylamino)-7-methoxy-1-nitroacridine and 9-(2 ′-acetoxyethylamino)-7-methoxy-4-methyl-1-nitroacridine and (b) at least one tumor inhibitor substance selected from the group consisting of a nucleic acid synthesis inhibitor, a cell cycle inhibitor and an anti-angiogenic substance.

A method for inhibiting tumor growth in a mammal comprising administering to said mammal at least 1-nitroacridine, wherein said 1-nitroacridine is selected from the group consisting of 1-nitro-4-alkyl-9-hydroxyalkylaminoacridine, 1-nitro-4-alkyl-9-hydroxyalkylaminoacridine, 1-nitro-9-alkoxyalkylaminoacridine and 1-nitro-9-alkylcarboxyalkylaminoacridine and at least one antiangiogenic substance, wherein the combination of 1-nitroacridine and antiangiogenic substance is an amount effective to inhibit tumor growth.

A method for inhibiting tumor growth in a mammal comprising administering to said mammal at least 1-nitroacridine, wherein said 1-nitroacridine is selected from the group consisting of 1-nitro-4-alkyl-9-hydroxyalkylaminoacridine, 1-nitro-4-alkoxy-9-hydroxyalkylaminoacridine, 1-nitro-9-alkoxyalkylaminoacridine and 1-nitro-9-alkylcarboxyalkylaminoacridine and at least one antiangiogenic substance, wherein the combination of 1-nitroacridine and antiangiogenic substance is an amount effective to inhibit metastases.

A method for inhibiting tumor growth in a mammal comprising administering to said mammal at least one 1-nitroacridine selected from the group consisting of 1-nitro-4-alkyl-9-hydroxyalkylaminoacridine, 1-nitro-4-alkyl-9-hydroxyalkylaminoacridine, 1-nitro-9-akoxyalkylaminoacridine and 1-nitro-9-alkylcarboxyalkylaminoacridine and at least one tumor inhibitor substance, wherein the tumor inhibitor substance is selected from the group consisting of an antiangiogenic substance, a nucleic acid synthesis inhibitor and a cell cycle inhibitor, wherein the combination of 1-nitroacridine and tumor inhibitor substance is an amount effective to inhibit tumor growth.

A method for inhibiting metastases in a mammal comprising administering to said mammal at least one 1-nitroacridine selected from the group consisting of 1-nitro-4-alkyl-9-hydroxyalkylaminoacridine, 1-nitro-4-alkyl-9-hydroxyalkylaminoacridine, 1-nitro-9-alkoxyalkylaminoacridine and 1-nitro-9-alkylcarboxyalkylaminoacridine derivative and at least one tumor inhibitor substance, wherein the tumor inhibitor substance is selected from the group consisting of an antiangiogenic substance, a nucleic acid synthesis inhibitor and a cell cycle inhibitor, wherein the combination of 1-nitroacridine and tumor inhibitor substance is an amount effective to inhibit metastases.

A method for inhibiting prostate tumor growth in a mammal comprising administering to said mammal a 1-nitroacridine selected from the group consisting of 1-nitro-4-alkyl-9-hydroxyalkylaminoacridine, 1-nitro-4-alkyl-9-hydroxyalkylaminoacridine, 1-nitro-9-alkylcarboxyalkylaminoacridine and 1-nitro-9-alkoxyalkylaminoacridine and a tumor inhibitor substance wherein the tumor inhibitor substance is selected from the group consisting of an antiangiogenic substance, a nucleic acid synthesis inhibitor and a cell cycle inhibitor, wherein the combination of 1-nitroacridine and tumor inhibitor substance is an amount effective to inhibit or prevent said prostate tumor growth.