Back to results
US 7,622,476 B2Granted
Methods of using 1-allyl ergot alkaloid derivatives to treat migraines
AssigneeAxxonis Pharma AG
InventorsMiroslav Flieger, Heinz Pertz, Karel Kranda, Jan Cvak, Sven Jaenichen, Erika Glusa
Life of this patent
Estimating the term…
Abstract
This invention relates to 1-allyl ergot alkaloids and their derivatives with selective antagonistic properties to 5-HT2 receptors for the prevention of, and relief from, migraine-related headache, Parkinson's disease, disorders of the thrombocyte function, etc.
Claims3
A method of treating migraines in a mammal comprising the step of administering a therapeutically effective amount of the compounds of the general formula (I)
- wherein
- R1 represents an ethyl, n-propyl, i-propyl, or allyl group,
- R4 represents hydrogen, a methyl, ethyl, n-propyl, i-propyl, or —CH2OH group, and
- the - - - bond between C atoms 9 and 10 is a single bond when the —OCH3 group (C10) is present or a double bond when the —OCH3 group (C10) is omitted and their pharmaceutically tolerable salts.
1 more element
Dependencies are inferred from the claim text.