Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders

A method of treating cognitive impairment associated with Alzheimer's disease, schizophrenia or related idiopathic psychoses, Huntington's disease, Tourette's syndrome, anxiety, affective disorders, drug-induced psychoses, psychoses secondary to neurodegenerative disorders, major depression, bipolar disorder, depression with psychotic features, or sleep disorders, comprising administering to a subject exhibiting one or more symptoms of cognitive impairment a therapeutically effective amount of a compound of Formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• A has the structure:
• wherein each bond represented by a dashed and solid line in A represents a carbon-carbon single bond;
• X is nitrogen;
• X′ is C;
• Y is nitrogen;
• W is nitrogen;
• each n is 1;
• R1 is hydrogen;
• L is absent;
• a, b, c, and d are each carbon,
• e, f, g, and h are each carbon,
• R2, R3, R4, and R5, are each separately selected from the group consisting of hydrogen, halogen, optionally substituted C1-6 alkyl, optionally substituted C1-6 alkyloxy, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted C1-6-alkoxyalkyl, optionally substituted C1-6 alkylthio, perhaloalkyl, CN, COR10, CONHR10, NHCONHR10, SO2NHR10, SO2R10, OSO2R10, NO2, NHCOR10,
• or R2 and R3, or R3 and R4, or R4 and R5 taken together, along with the ring carbons to which they are attached, form a five-membered or six-membered cycloalkyl, heterocyclyl or heteroaryl ring, or a six-membered aryl ring moiety;
• R6, R7, R8, and R9, are each separately selected from the group consisting of hydrogen, halogen, optionally substituted C1-6 alkyl, optionally substituted C1-6 alkyloxy, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted C1-6-alkoxyalkyl, optionally substituted C1-6 alkylthio, perhaloalkyl, CN, COR10, CONHR10, NHCONHR10, SO2NHR10, SO2R10, OSO2R10, NO2, NHCOR10,
• or R6 and R7, or R7 and R8, or R8 and R9 taken together, along with the ring carbons to which they are attached, form a five-membered or six-membered cycloalkyl, heterocyclyl or heteroaryl ring, or a six-membered aryl ring moiety;
• Z is oxygen;
• R10 is selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, optionally substituted C3-8 cycloalkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl optionally substituted aryl, optionally substituted arylalkyl, and perhaloalkyl;
• and
• each bond represented by a dashed and solid line in Formula I represents a carbon-carbon double bond.