Methods for slowing familial ALS disease progression
AssigneeIsis Pharmaceuticals, Inc.
InventorsC. Frank Bennett, Susan M. Freier, Thomas P. Condon
Life of this patent
Estimating the term…
Abstract
Methods for slowing disease progression in an individual suffering from familial ALS are provided. Also provided are methods of increasing the survival time of an individual suffering from familial ALS. These methods employ antisense oligonucleotides targeted to SOD1, for use in inhibiting the expression of SOD1 in the central nervous system of an individual suffering from familial ALS.
Claims20
A method of treating amyotrophic lateral sclerosis (ALS) comprising administering to the cerebrospinal fluid of a subject in need thereof a therapeutically or prophylactically effective amount of a composition comprising:
- a modified oligonucleotide consisting of 12 to 30 linked nucleosides having a nucleobase sequence comprising an 8-nucleobase portion of SEQ ID NO:
- 3, wherein the modified oligonucleotide is specifically hybridizable with SEQ ID NO:
- 1, and
- a pharmaceutically acceptable diluent or carrier.
A method of treating amyotrophic lateral sclerosis (ALS) comprising administering to the cerebrospinal fluid of a subject in need thereof a therapeutically or prophylactically effective amount of a composition comprising:
- a modified oligonucleotide consisting of 12 to 30 linked nucleosides having a nucleobase sequence comprising an 8-nucleobase portion of SEQ ID NO:
- 3, wherein the modified oligonucleotide is 100% complementary to SEQ ID NO:
- 1, and
- a pharmaceutically acceptable diluent or carrier.
Dependencies are inferred from the claim text.