Flavone C-glycoside derivatives and compositions containing the derivatives
AssigneeSuntory Holdings Limited
InventorsYoshiyuki Ishikura, Kuniro Tsuji, Haruo Nukaya
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AssigneeSuntory Holdings Limited
InventorsYoshiyuki Ishikura, Kuniro Tsuji, Haruo Nukaya
Estimating the term…
The present invention relates to novel flavone C-glycoside derivatives or salts thereof, especially those showing an anti-allergic effect, and compositions containing them. Recently, cases of allergic diseases, especially pollenosis and atopic dermatitis have increased to such a degree that they have become a social problem. Flavones and their glycosides have been reported to have the effect of inhibiting histamine release from mast cells or an immunosuppressive effect and expected for application as allergy therapies. However, most flavones exhibit their effects only at high doses, so that effective compounds at lower doses are highly desired. The present invention provides novel components capable of treating allergic diseases at low doses and compositions containing them.
An isolated flavone C-glycoside derivative of formula (1):
An isolated flavone C-glycoside derivative of formula (2):
A flavone C-glycoside derivative of formula (1) purified to at least about 0.001 weight % dry solids:
A flavone C-glycoside derivative of formula (2) purified to at least about 0.001 weight % dry solids:
Dependencies are inferred from the claim text.