Anti-hypercholesterolemic compounds

A compound of Formula I

• and the pharmaceutically acceptable salts and esters thereof, wherein
• Ar1 is selected from the group consisting of aryl and R4-substituted aryl;
• X, Y and Z are independently selected from the group consisting of —CH2—, —CH(C1-6alkyl)- and —C(C1-6alkyl)2—;
• R is selected from the group consisting of —OR6, —O(OC)R6, —O(OC)OR8, —O(CO)OR9, —O(CO)NR6R7, a sugar residue, a disugar residue, a trisugar residue and a tetrasugar residue;
• R1 is selected from the group consisting of —H, —C1-6alkyl and aryl, or R and R1 together are oxo;
• R2 is selected from the group consisting of —OR6, —O(CO)R6, —O(CO)OR8, —O(CO)OR9 and —O(CO)NR6R7;
• R3 is selected from the group consisting of —H, —C1-6alkyl and aryl or R2 and R3 together are oxo;
• q and r are integers each independently selected from 0 and 1;
• t is an integer selected from 0, 1 and 2;
• m, n and p are integers each independently selected from 0, 1, 2, 3 and 4;
• R4 is 1-5 substituents independently selected at each occurrence from the group consisting of:
• —OR5, —O(CO)R5, —O(CO)OR8, —O—C1-5alkyl-OR5, —O(CO)NR5R6, —NR5R6, —NR5(CO)R6, —NR5(CO)OR8, —NR5(CO)NR6R7, —NR5SO2R8, —COOR5, —CONR5R6, —COR5, —SO2NR5R6, —S(O)tR8, —O—C1-10alkyl-COOR5, —O—C1-10alkyl-CONR5R6 and fluoro;
• R5, R6 and R7 are independently selected at each occurrence from the group consisting of —H, C1-6alkyl, aryl and aryl-substituted C1-6alkyl;
• R8 is independently selected from the group consisting of C1-6alkyl, aryl and aryl-substituted C1-6alkyl;
• R9 is selected from the group consisting of —C≡C—CH2—NR10R11, —C≡C—C(O)R13, and —(CH2)3—NR10R14;
• R10 is independently selected at each occurrence from —H and —C1-3alkyl;
• R11 is selected from the group consisting of —H, —C1-3alkyl, —C(O)—C1-3alkyl, —C(O)—NR10R10, —SO2—C1-3alkyl, and —SO2-phenyl;
• R12 is selected from the group consisting of:
• R13 is selected from the group consisting of —OH and —NR10R11;
• and
• R14 is selected from the group consisting of —C(O)—C1-3alkyl, —C(O)—NR10R10, —SO2—C1-3alkyl and —SO2-phenyl.