Use of glutathione synthesis stimulating compounds in reducing insulin resistance

A pharmaceutical composition comprising:

• a) a therapeutically effective amount of hepatic glutathione increasing compound for reducing insulin resistance, wherein the hepatic glutathione increasing compound is at least one of N-acetylcysteine, cysteine esters, L-2-oxothiazolidine-4-carboxolate (OTC), gamma glutamylcysteine and its ethyl ester, glutathione ethyl ester, glutathione isopropyl ester, lipoic acid, cystine, cysteine, methionine, or S-adenosylmethionine (SAMe), and
• b) a therapeutically effective amount of hepatic nitric oxide donor for reducing insulin resistance, wherein the hepatic nitric oxide donor is at least one of SIN-1, molsidamine, nitrosylated N-acetylcysteine, nitrosylated cysteine esters, nitrosylated L-2-oxothiazolidine-4-carboxolate (NOTC), nitrosylated gamma glutamylcysteine and its ethyl ester, nitrosylated glutathione ethyl ester, nitrosylated glutathione isopropyl ester, nitrosylated lipoic acid, nitrosylated cysteine, nitrosylated cystine, nitrosylated methionine, or nitrosylated S-adenosylmethionine,
• wherein the hepatic glutathione increasing compound and the hepatic nitric oxide donor are independently bound to albumin or a bile salt.