US 7,622,446 B2 · Polypeptides, derivatives and uses thereof

Abstract

The invention provides a compound having formula X1-Arg-Xaa-Arg-X2 in which X1 and X2 are up to 30 amino acid residues and Xaa is an amino acid residue. A preferred compound is the tripeptide Arg-Glu-Arg which corresponds to amino acid residues 328 to 330 of human amyloid precursor protein. The invention further provides a derivative of a polypeptide having the formula: X1-Arg-Xaa-Arg-X2 wherein X1 and X2, which may be the same or different, each represents from zero to 30 natural or synthetic amino acid residues or derivatives thereof and Xaa represents a natural or synthetic amino acid residue or derivative thereof, at least one functional group of at least one said amino acid residue or derivative thereof being protected by a protective group. The compounds of the invention are believed to be useful in the treatment of Alzheimer's disease and as cognitive enhancers.

Claims17

Dependent claims

A pharmaceutical composition comprising:

(a) a peptide consisting of the following sequence of amino acids:
Arg-Glu-Arg (I)
wherein each amino acid residue is in the D-form or the L-form or in the form of a salt thereof, at least one functional group of the N-terminal arginine residue of said peptide being protected by at least one protective group, and (b) pharmaceutically acceptable carrier, filler, or excipient.

Dependencies are inferred from the claim text.

Polypeptides, derivatives and uses thereof

Life of this patent

Polypeptides, derivatives and uses thereof

Life of this patent

Abstract

Claims17