Methods for using OX-40 ligand to enhance an antigen specific immune response
AssigneeSisters of Providence in Oregon
InventorAndrew D. Weinberg
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Abstract
Compositions and methods for enhancing the immune response of a mammal to an antigen by engaging the OX-40 receptor on the surface of T-cells are disclosed, comprising administering to the mammal a composition comprising a purified OX-40 receptor binding agent and a pharmaceutically acceptable carrier, wherein the composition is administered to the mammal such that the OX-40 receptor binding agent is presented to T-cells of the mammal during or shortly after priming of the T-cells by the antigen. Such compositions and methods can be used in immunization and cancer treatment.
Claims11
A method of enhancing the immune response of a mammal to an antigen, comprising administering to the mammal a composition comprising a purified OX-40-ligand (OX-40L) and a pharmaceutically acceptable carrier, wherein said composition is administered to the mammal such that the OX-40L is presented to T-cells of the mammal during or shortly after priming of the T-cells by the antigen, wherein the composition comprises about 10 ng to 1 gram of OX-40L.
A method for stimulating the immune response of a mammal to a tumor cell in the mammal, comprising administering to the mammal a therapeutically effective dose of a purified OX-40 ligand (OX-40L).
A method of causing enhanced immune response against a tumor in a mammal, the method comprising increasing the amount of an X-40 ligand (OX-40L) at the tumor site.
Dependencies are inferred from the claim text.