Method to enhance hemodynamic stability using oxygen carrying compositions
AssigneeSangart, Inc.
InventorsRobert M. Winslow, Kim D. Vandegriff
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Abstract
The present invention relates to methods for enhancing the hemodynamic stability of an individual undergoing surgery by administering a composition comprising a hemoglobin-based oxygen carrier. In one embodiment, the present invention relates to the use of polyalkylene oxide modified hemoglobins with reduced cooperativity and a high oxygen affinity to enhance oxygen offloading as a preventative measure to avoid hemodynamic stability-related complications during surgery.
Claims9
A method for reducing hypotensive events that may be experienced by a normovolemic subject during surgery while under general anesthesia, said method comprising the steps of:
- a) providing a modified hemoglobin having an oxygen affinity higher than native hemoglobin in whole blood and a reduced cooperativity relative to native hemoglobin;
- b) administering the modified hemoglobin to the subject before the surgery;
- and
- c) monitoring blood pressure of the subject after administering the modified hemoglobin and during surgery to detect hypotension;
- wherein the subject did not undergo an acute normovolemic hemodilution treatment in connection with the surgery.
Dependencies are inferred from the claim text.