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US 7,622,438 B1Granted
Protein formulation for promoting hard tissue formation
AssigneeAcologix, Inc.
InventorsMirella Lazarov, Catherine Middleton-Hardie, David Rosen
Life of this patent
Estimating the term…
Abstract
Formulations and methods to promote biological processes to form or regenerate new hard tissues such as bones, cartilage, and/or dental tissues are disclosed. The formulation enhances biological activities of a hard tissue growth and differentiation factor characterized by specific and selective upregulation and/or extension of the retention time of the intracellular enzymes and signaling molecules that play important roles to proliferate, differentiate, maturate, and/or mineralize the hard tissue forming cells.
Claims6
A formulation, comprising:
- a pharmaceutically acceptable carrier;
- a peptide consisting of the amino acid sequence of TDLQERGDNDISPFSGDGQPFKD (SEQ ID NO:8);
- and
- recombinant human bone morphogenic protein-2 (rhBMP-2);
- wherein the peptide and the rhBMP-2 are present in amounts such that together they upregulate and activate cyclooxygenase-2 in hard tissue forming cells and increase production of prostaglandin E2 by the hard tissue forming cells,
- wherein the ratio of the rhBMP-2 to the peptide is in a range of 1:5 or more.
3 more elements
A kit, comprising:
- a pharmaceutically acceptable carrier;
- a pre-measured amount of a peptide consisting of the amino acid sequence of TDLQERGDNDISPFSGDGQPFKD (SEQ ID NO:8;
- a pre-measured amount of recombinant human bone morphogenic protein-2 (rhBMP-2);
- and
- instructions for combining and administering the carrier, peptide and rhBMP-2 ,
- wherein the peptide and rhBMP-2 are present in amounts such that together they upregulate and activate cyclooxygenase-2 in hard tissue forming cells and increase production of prostaglandin E2 by the hard tissue forming cells,
- wherein the ratio of the rhBMP-2 to the peptide is in a range of 1:5 or more.
4 more elements
Dependencies are inferred from the claim text.