Tissue factor compositions and methods
AssigneeThe Board of Trustees of the University of Illinois
InventorsJames H. Morrissey, Vincent S. Pureza, Stephen G. Sligar
Life of this patent
Estimating the term…
Abstract
Tissue Factor (natural or recombinant truncated) can be incorporated into stable, soluble nanoscale particles so that activity is maintained. These particles can be used as a reagent in prothrombin clotting time assays or they can be used in therapeutic compositions for use in humans or animals. Therapeutic settings can include supplementation in the case of a genetic deficiency, uncontrolled bleeding, surgical incisions or seepage, thrombocytopenia, soft tissue trauma or other trauma, to effect tumor regression or to inhibit tumor growth.
Claims8
A method for controlling bleeding in a human or animal patient, said method comprising the step of administering, in an amount effective to control bleeding in said patient a composition comprising nanoscale particles comprising tissue factor or recombinant tissue factor, a membrane scaffold protein and phospholipid, wherein the phospholipid comprises a net-negatively charged phospholipid, and wherein said nanoscale particles are attached to a solid support, whereby bleeding in said patient is controlled.
Dependencies are inferred from the claim text.