Process for improving the manufacture of clavams e.g. clavulanic acid
AssigneesGlaxo Group Limited, The Governors of the University of Alberta
InventorsBarry Barton, Alison Michelle Griffin, Susan Jensen, Annie Wong
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Abstract
New processes for improving the manufacture of clavams e.g. clavulanic acid. Novel DNA sequences and new microorganisms capable of producing increased amounts of clavulanic acid are also disclosed.
Claims2
An isolated S. clavuligerus microorganism comprising DNA from which SEQ ID NO:1 has been disrupted or deleted such that the production of 5S clavams by said S. clavuligerus is reduced and clavulanic acid production is at least maintained when compared with a S. clavuligerus comprising SEQ ID NO:1 which has not been disrupted or deleted.
An isolated S. clavuligerus microorganism comprising DNA from which SEQ ID NO:1 and one or more of:
- SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:10, and SEQ ID NO:11 have been disrupted or deleted such that the production of 5S clavams by said S. clavuligerus is reduced and clavulanic acid production is at least maintained when compared with a S. clavuligerus which has not had said open reading frames disrupted or deleted.
Dependencies are inferred from the claim text.