Molecular microarrays and helical peptides
OwnerEdelmira Cabezasinventor
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Abstract
Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of branched peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner. Additionally, peptides that adopt helical structures are synthesized on a substrate surface and arrays are created having one or more features containing peptides capable of forming helixes.
Claims16
An array of polymers attached to a substrate wherein the array comprises a support structure having a surface, wherein the surface has a plurality of features, wherein each of the features comprises a plurality of peptides of known sequence attached to the substrate surface, wherein the sequence of peptides in a first feature of the array is different from the sequence of peptides in a second feature of the array, wherein at least one feature of the array comprises a first peptide and a second peptide attached to the surface of the support structure through a bifurcation molecule or a trifunctional linker molecule, and wherein the first and second peptide are capable of forming a helical structure, and wherein the bifurcation molecule or the trifunctional linker molecule is attached to the first and to the second peptide.
An object comprising a substrate having a surface wherein a polymer is attached to the substrate surface, wherein the polymer is comprised of a first and a second peptide and the first and the second peptides are attached to the substrate through a single bifurcation molecule or a trifunctional linker molecule and wherein the first and the second peptides are capable of forming a helical structure, and wherein the bifurcation molecule or the trifunctional linker molecule is attached to the first and to the second peptide.
Dependencies are inferred from the claim text.