Process for the production of biodegradable, functionalised polymer particles, and use thereof as pharmaceutical supports

A process for producing polyhydroxy carboxylate particles having surface-bound proteins, the process comprising:

• A) providing a cell comprising at least one gene that codes for a fusion protein, the fusion protein comprising
• (a) a polymer synthase from a microorganism of the genera Ralstonia, Alcaligenes, Pseudomonas, Aeromonas, or Thiocapsa, and
• (b) at least one protein selected from an oligopeptide, antibody, non-catalytic protein or enzyme, fused with the N-terminus of the polymer synthase, the polymer synthase comprising a polymer particle binding domain;
• B) cultivating the cell in a culture medium so that the cell produces the fusion protein from the at least one gene and produces polymer particles comprising polyhydroxy carboxylate, wherein the polymer particle binding domain of the fusion protein is bound to a polymer particle;
• and
• C) separating the polymer particles from the cultivated cells to produce a composition comprising polyhydroxy carboxylate particles having surface-bound proteins.