Low-density lipoprotein receptor 6 (LRP6) as a mammary stem cell marker and related methods
AssigneeVan Andel Research Institute
InventorsBart O. Williams, Charlotta Lindvall
Life of this patent
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Abstract
A method for enriching a population of somatic mammary stem cells or mammary tumor stem cells based on low-density lipoprotein receptor-related protein 6 (LRP6). Also included are methods for screening for LRP6 modulators, as well as methods for reducing Wnt signaling, for treating Wnt signaling-related diseases, for detecting mammary basal-like cells, for diagnosing basal-like breast cancer, and for inhibiting proliferation of a tumor expressing LRP6, and compositions thereof.
Claims9
A method for selecting mammary stem cells or mammary tumor stem cells from a population of mammary cells mammary tumor cells, the method comprising the steps of:
- obtaining a population of mammary cells or mammary tumor cells containing one or more somatic mammary stem cells or mammary tumor stem cells;
- contacting said population of mammary cells or mammary tumor cells with an LRP6 antibody;
- and
- selecting cells that bind to the antibody.
Dependencies are inferred from the claim text.