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US 7,622,265 B2Granted
Methods and compositions for modulating prostasin
AssigneeGenentech, Inc.
InventorsBin Fan, Daniel K. Kirchhofer
Life of this patent
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Abstract
The invention provides methods and compositions related to modulating prostasin.
Claims11
A method of screening for a candidate inhibitor substance that inhibits HAI-1/1B inhibition of prostasin, said method comprising:
- (a) contacting a candidate substance with a first sample comprising prostasin, HAI-1/1B, and a prostasin substrate, and (b) comparing amount of prostasin activity in the sample with amount of prostasin activity in a control sample that has not been contacted with said candidate substance, whereby an increase in amount of prostasin activity in the first sample compared to the controt sample indicates that the candidate substance is capable of inhibiting HAI-1/1B inhibition of prostasin.
A method of screening for a candidate inhibitor substance that blocks specific binding between prostasin and HAI-1/1B, said method comprising (a) contacting a candidate substance with purified prostasin andlor purified HAI-1/1B, and (b) detecting binding, if any, to the prostasin and or HAI-1/1B.
Dependencies are inferred from the claim text.