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US 7,622,146 B2Granted
Rate limiting barriers for implantable devices and methods for fabrication thereof
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorsWouter E. Roorda, Syed F. A. Hossainy, Ni Ding, Fuh-Wei Tang, Stephen D. Pacetti
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Abstract
A method of coating an implantable medical device, such as a stent, is disclosed. The method includes applying a formulation on a first polymer layer containing a therapeutic substance to form a second layer. The formulation can contain a highly hydrophobic polymer or a solvent which is a poor solvent for the drug or the polymer of the first layer. The formulation can have a low surface tension value or a high Weber number value.
Claims7
A method for coating an implantable medical device, the method comprising:
- (a) forming a first layer on the device, the first layer comprising a first polymer and a therapeutic substance incorporated therein;
- and
- (b) applying a formulation on the first layer to form a second layer, the formulation comprising a second polymer and a solvent, the solvent having an evaporation rate of at least three times greater than the evaporation rate of butyl acetate,
- wherein the solvent is a poor solvent for the therapeutic substance and the first polymer such that the therapeutic substance and the first polymer each have a solubility in the solvent of less than about 1.0 mass % at room temperature, wherein the second polymer has a greater degree of hydrophobicity than the first polymer.
1 more element
Dependencies are inferred from the claim text.