Calcium phosphate delivery vehicles for osteoinductive proteins
AssigneesWyeth, Etex Corporation
InventorsRebecca Li, Howard Seeherman, Aliassghar Tofighi
Life of this patent
Estimating the term…
Abstract
A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.
Claims9
A composition for delivery of osteogenic proteins, which comprises at least one osteogenic protein as a first biologically active agent, a calcium phosphate material as a carrier, and an effective amount of a material that liberates gas upon dissolution in vivo, wherein the at least one osteogenic protein comprises a member of the TGF-β family.
Dependencies are inferred from the claim text.