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US 7,622,135 B2Granted
Coated stent
Assigneeev3 Peripheral, Inc.
InventorsChandrashekhar Pathak, Rama Akella, John Ranieri
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Abstract
Stents with coatings comprising a combination of a restenosis inhibitor comprising an HMG-CoA reductase inhibitor and a carrier. Also provided are methods of coating stents with a combination of an HMG-CoA reductase inhibitor and a carrier. A preferred example of a restenosis inhibitor is cerivastatin. The stent coatings have been shown to release restenosis inhibitors in their active forms.
Claims6
A coated stent comprising:
- a coating composition comprising an HMG-CoA reductase inhibitor in an effective amount, of about 1 to 50 wt.-%, and a polymeric carrier component;
- wherein the polymeric carrier component comprises a polymer selected from polycaprolactone, ethylene-vinyl acetate polymer, and a two-part silicone rubber,
- wherein the HMG-CoA reductase inhibitor is selected from the group consisting of cerivastatin, fluvastatin, simvastatin, lovastatin, atorvastatin, pravastatin and mixtures thereof, and
- wherein the HMG-CoA reductase inhibitor is released from the coated stent at a rate of >20 μg/ml per day.
1 more element
Dependencies are inferred from the claim text.