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US 7,622,108 B2Granted
Multi-lineage progenitor cells
AssigneeBioE, Inc.
InventorsDaniel P. Collins, Stacey L. Sprague, Barbara M. Tigges
Life of this patent
Estimating the term…
Abstract
Fetal blood multi-lineage progenitor cells that are capable of a wide spectrum of transdifferentiation are described.
Claims6
A method of characterizing a population of multi-lineage progenitor cells (MLPC), said method comprising:
- a) providing a purified population of MLPC, wherein said MLPC are positive for CD9, CD13, CD29, CD44, CD73, CD90 and CD105, and negative for CD10, CD34, CD41, CD45, Stro-1, Stage Specific Embryonic Antigen-3 (SSEA-3) and SSEA-4;
- and b) assessing expression in said population of MLPC of at least one mRNA selected from the group consisting of CXCR4, FLT3, CD133, ICAM2, ITGAX, TFRC, KIT, IL6R, IL7R, ITGAM, FLT3, PDGFRB, SELE, SELL, TFRC, ITGAL, ITGB2, PECAM1, ITGA2B, ITGA3, ITGA4, ITGA6, ICAM1, CD24, CD34, CD44, CD45, CD58, CD68, CD33, CD37, CD38, TERT and POU5F.
Dependencies are inferred from the claim text.