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US 7,622,106 B1Granted
Necrosis assay
AssigneeBoard of Regents, The University of Texas System
InventorsXiaodong Wang, Sudan He, Lai Wang
Life of this patent
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Abstract
A necrosis assays is performed with a cell expressing RIPK1 and RIP3 by (a) culturing the cell with a smac mimetic, caspase-8 inhibitor and TNF-α; and (b) detecting a resultant necrosis of the cell.
Claims8
A method of inducing necrosis in a mammalian cell expressing RIPK1 and RIP3, comprising the steps of:
- (a) culturing the cell with a smac mimetic, caspase-8 inhibitor and TNF-α;
- and
- (b) detecting a resultant necrosis of the cell.
Dependencies are inferred from the claim text.