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US 7,621,740 B2Granted
Mahonia aquifolium extract, extraction process and pharmaceutical composition containing the same
AssigneePrime Pharmaceutical Corporation
InventorsRobert Mills, Rajiv Mathur, Nadya Lawrence
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Abstract
A skin treatment composition comprising a Mahonia aquifolium extract in a liposome delivery system is described. The Mahonia aquifolium extract is present in the skin treatment composition in a range of from 5% to 20% by weight of the total composition. The skin treatment composition is particularly effective in the treatment of psoriasis, eczema and other dry skin conditions. A process for obtaining an extract of Mahonia aquifolium is also disclosed.
Claims4
A process for obtaining an extract of Mahonia aquifolium comprising the steps of:
- (a) applying heat and pressure to a stirred mixture of water, alcohol and crude dried Mahonia aquifolium, to heat the mixture to a temperature not higher than 50° C., and to a pressure between 3 and 6 psi;
- (b) processing the mixture with a grinder at a speed about 3000 rpm for about three hours;
- (c) allowing the mixture to cool under pressure for at least 24 hours;
- (d) repeating the last two steps at least twice more;
- (e) releasing the pressure and filtering the mixture to obtain a filtrate;
- (f) placing the filtrate under vacuum and heating the filtrate to a temperature not higher than 50° C. while stirring to reduce and remove the alcohol and water until the filtrate is approximately 6% of its original volume to obtain a heated filtrate;
- and (g) filtering the heated filtrate though a 5 micron filter to obtain the extract of Mahonia aquifolium.
4 more elements
Dependencies are inferred from the claim text.