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AssigneeArdian, Inc.
InventorsDenise Demarais, Benjamin J. Clark, Nicolas Zadno, Erik Thai, Hanson Gifford, III
Estimating the term…
Methods and apparatus are provided for pulsed electric field neuromodulation via an intra-to-extravascular approach, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation and other conditions in target neural fibers. In some embodiments, the ITEV PEF system comprises an intravascular catheter having one or more electrodes configured for intra-to-extravascular placement across a wall of patient's vessel into proximity with target neural fibers. With the electrode(s) passing from an intravascular position to an extravascular position prior to delivery of the PEF, a magnitude of applied voltage or energy delivered via the electrode(s) and necessary to achieve desired neuromodulation may be reduced relative to an intravascular PEF system having one or more electrodes positioned solely intravascularly. The methods and apparatus of the present invention may, for example, be used to modulate one or more target neural fibers that contribute to renal function.
An apparatus for electric field neuromodulation via an intra-to-extravascular approach, the apparatus comprising:
The apparatus of claim I further comprising a piercing element configured for intravascular delivery, the piercing element configured to pierce a wall of vasculature of a patient from within the vasculature.
An apparatus for electric field neuromodulation via an intra-to-extravascular approach, the apparatus comprising:
An apparatus for electric field neuromodulation via an intra-to-extravascular approach, the apparatus comprising:
An apparatus for electric field neuromodulation via an intra-to-extravascular approach, the apparatus comprising:
A method for electric field neuromodulation via an intra-to-extravascular approach, the method comprising:
Dependencies are inferred from the claim text.