Encapsulated amyloid-beta peptides
AssigneeIntezyne Technologies, Inc.
InventorsKurt Breitenkamp, Habib Skaff, Kevin N. Sill
Life of this patent
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Abstract
The present invention relates to the field of polymer chemistry and more particularly to encapsulated peptides and uses thereof.
Claims10
A micelle having an amyloid (1-42) peptide or fragment or mutant peptide thereof, encapsulated therein,
- wherein the amyloid-beta (1-42) peptide or fragment or mutant peptide is selected from the group consisting of SEQ ID Nos:
- 1-20 and wherein the micelle comprises a multiblock copolymer selected from the following compounds of the formula:
- wherein each w is 25-1000, each x is 1-50, each y is 1-50, each z is 1-100, p is the sum of y and z, and each dotted bond represents the point of attachment to the rest of the molecule:
- Compound
- A1
- A2
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- Compound
- A3
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- E2
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A micelle having an amyloid-beta (1-42) peptide or fragment or mutant peptide thereof, encapsulated therein,
- wherein the amyloid-beta (1-42) peptide or fragment or mutant peptide is selected from the group consisting of SEQ ID NOs:
- 1-20 and wherein the micelle comprises a multiblock copolymer selected from the following compounds of the formula:
- wherein each x is 100-500, each y is 4-20, each z is 5-50, and each dotted bond represents the point of attachment to the rest of the molecule:
- Compound
- A1
- A2
- E1
- E2
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A micelle having an amyloid-beta (1-42) peptide or fragment or mutant peptide thereof, encapsulated therein,
- wherein the amyloid-beta (1-42) peptide or fragment or mutant peptide is selected from the group consisting of SEQ ID NOs:
- 1-20 and wherein the micelle comprises a multiblock copolymer selected from the following compounds of the formula:
- wherein each v is 100-500, each w is 4-20, x is 4-20, each y is 5-50, each z is 5-50, p is the sum of y and z, and each dotted bond represents the point of attachment to the rest of the molecule:
- Compound
- A1
- A2
- A3
- A4
- E1
- E2
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A micelle having an amyloid-beta (1-42) peptide or fragment or mutant peptide thereof, encapsulated therein,
- wherein the amyloid-beta (1-42) peptide or fragment or mutant peptide is selected from the group consisting of SEQ ID NOs:
- 1-20 and wherein the micelle comprises a multiblock copolymer selected from the following compounds of the formula:
- wherein each w is 25-1000, each x is 1-50, y is 1-50, each z is 1-100, and each dotted bond represents the point of attachment to the rest of the molecule:
- Compound
- A1
- A2
- A3
- E1
- E2
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A micelle having an amyloid-beta (1-42) peptide or fragment or mutant peptide thereof, encapsulated therein,
- wherein the amyloid-beta (1-42) peptide or fragment or mutant peptide is selected from the group consisting of SEQ ID NOs:
- 1-20 and wherein the micelle comprises a multiblock copolymer selected from:
- wherein each n is 200-300, each m is 5-15, each x is 1-100, each y is 1-100, and each m′ is 20-100 such that x+y =m′.
A micelle having an amyloid-beta (1-42) peptide or fragment or mutant peptide thereof, encapsulated therein,
- wherein the amyloid-beta (1-42) peptide or fragment or mutant peptide is selected from the group consisting of SEQ ID NOs:
- 1-20 and wherein the micelle comprises a multiblock copolymer selected from:
- wherein each n is 200-300, each x is 1-100, each y is 1-100, and each m′ is 20-100 such that x+y=m′.
Dependencies are inferred from the claim text.