# US 7,613,495 B2 · MRI detection and staging of Parkinson's disease and detection of progressive supranuclear palsy > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 7,613,495 B2 - Document ID: US7613495B2 - Status: Granted - Kind: B2 - Application number: 09/997,894 - Filed: 2001-11-30 - Published: 2002-08-22 - Granted: 2009-11-03 - Earliest claimed: 2000-11-30 - Assignees: Advanced MRI Technologies, LLC - Inventors: Michael Hutchinson - Web page: https://patentgrep.com/patent/US7613495B2 ## CPC - G06T 7/0012: {Biomedical image inspection} - A61B 5/055: involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging - A61B 5/4082: {Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette} - G01R 33/483: with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy - G01R 33/4838: {using spatially selective suppression or saturation of MR signals} - G01R 33/50: based on the determination of relaxation times {, e.g. T1 measurement by IR sequences; T2 measurement by multiple-echo sequences} - G06T 2207/30016: Brain - G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12) ## Abstract A method of detecting Parkinson's disease through MRI of substantial nigra pars compacta (SNc) tissue. The method involves obtaining a gray matter suppressed (GMS) MRI signal from the SNc tissue, obtaining a white matter suppressed (WMS) MRI signal of the SNc tissue, and combining information from the GMS and WMS MRI signals to produce resultant signals indicative of Parkinson's disease. A similar method can be used to detect Progressive Supranuclear Palsy. A method of distinguishing between the two diseases involves obtaining at least two starting MRI images of SNc tissue using different MRI parameters, and combining the starting images to compute resultant signals differentiating between the two forms of parkinsonism. ## Claims ### Claim 1 A method of detecting Parkinson's disease (PD) through operating a magnetic resonance imaging (MRI) apparatus performing MRI of brain tissue that includes substantia nigra pars compacts (SNc) tissue comprising: obtaining a gray matter suppressed (GMS) MRI signal of brain tissue that includes said SNc tissue by operating said MRI apparatus; obtaining a white matter suppressed (WMS) MRI signal of brain tissue that includes said SNc tissue by operating said MRI apparatus; processing information from said GMS and WMS MRI signals to produce and present resultant signals indicative of PD by computer-processing; and including forming and displaying, by computer processing, GMS and WMS images using information from said GMS and WMS signals. ### Claim 2 (depends on 1) A method as in claim 1 in which said obtaining of each of the GMS and WMS MRI signals comprises using an inversion recovery (IR) pulse sequence. ### Claim 3 (depends on 2) A method as in claim 2 wherein said processing of information from said GMS and WMS signals comprises processing at least portions of said GMS and WMS images. ### Claim 4 (depends on 3) A method as in claim 3 in which said processing of information from said GMS and WMS signals comprises obtaining a ratio image of at least portions of said GMS and WMS images for at least one MRI slice. ### Claim 5 (depends on 4) A method as in claim 4 further comprising processing selected medial and lateral regions of interest in each ratio image to derive a numerical measure indicative of the presence and/or staging of PD. ### Claim 6 (depends on 1) A method as in claim 1 further including using the resultant signals to stage PD. ### Claim 7 (depends on 1) A method as in claim 1 including plotting the resultant signals in a two-dimensional plot in which markers for patients with PD appear in an area different from that for patient without PD. ### Claim 8 (depends on 7) A method as in claim 7 in which the markers for patient with PD appear in different areas of the plot corresponding to different stages of PD. ### Claim 9 (depends on 1) A method as in claim 1 including causing said resultant signals to be indicative of a relative loss of MRI signal from lateral as compared with medial portions of the SNc. ### Claim 10 A method of detecting Progressive Supranuclear Palsy (PSP) through operating a magnetic resonance imaging (MRI) apparatus performing MRI of brain tissue that includes substantia nigra pars compacta (SNc) tissue comprising: obtaining a gray matter suppressed (GMS) MRI signal of brain tissue that includes said SNc tissue by operating said MRI apparatus; obtaining a white matter suppressed (WMS) MRI signal of brain tissue that includes said SNc tissue by operating said MRI apparatus; processing information from said GMS and WMS MRI signals to produce and present resultant signals indicative of PSP by computer-processing; and including forming and displaying, by computer processing, GMS and WMS images using information from said GMS and WMS signals. ### Claim 11 (depends on 10) A method as in claim 10 including causing said resultant signals to be indicative of a relative loss of MRI signal from medial as compared with lateral portions of the SNc. ### Claim 12 A method of distinguishing between two forms of parkinsonism radiographically, Parkinson's disease (PD) and Progressive Supranuclear Palsy (PSP) through operating a magnetic resonance imaging (MRI) apparatus performing MRI of brain tissue that includes substantia nigra pars compacta (SNc) tissue comprising: obtaining at least two starting MRI images of brain tissue that includes said SNc tissue using different MRI parameters by operating said MRI apparatus; and computer-processing the starting images to compute and present resultant signals differentiating between PD and PSP and displaying results of said computer-processing on display equipment. ### Claim 13 (depends on 12) A method as in claim 12 in which the at least two starting images comprise a gray matter suppressed (GMS) MRI image and a white matter suppressed (WMS) MRI image of brain tissue that includes said SNc tissue in the same MRI slice. ### Claim 14 (depends on 13) A method as in claim 13 in which each of said GMS and WMS image is obtained using an inversion-recovery MRI pulse sequence. ### Claim 15 A method of detecting Progressive Supranuclear Palsy (PSP) through operating a magnetic resonance imaging (MRI) apparatus performing MRI of brain tissue that includes substantia nigra pars compacta (SNc) tissue comprising: obtaining at least two starting MRI images of brain tissue that includes said SNc tissue using different MRI parameters by operating said MRI apparatus; and computer-processing the starting images and computing and presenting resultant signals indicative of and identifying PSP and displaying results of said computer-processing on display equipment. ### Claim 16 (depends on 15) A method as in claim 15 in which the at least two starting images comprise a gray matter suppressed (GMS) MRI image and a white matter suppressed (WMS) MRI image of brain tissue that includes said SNc tissue in the same MRI slice. ### Claim 17 (depends on 16) A method as in claim 16 in which each of said GMS and WMS images is obtained using an inversion-recovery MRI pulse sequence.